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Latest Biochemistry of Alzheimer's disease Stories

2011-10-03 22:23:47

Laser technique allows detailed view of the early minutes of amyloid aggregate formation -- implications for Alzheimer's disease drug discovery Researchers at the University of Toronto Scarborough (UTSC) and Osaka University applied a new approach to take a close look at amyloid plaque formation, a process that plays important roles in Alzheimer's disease. The technique would greatly aid the development and screening for novel therapeutics that can manipulate the formation of the toxic...

2011-09-28 09:21:34

Animal study may suggest way to rescue cells from disease A protein linked to Alzheimer's disease kills nerve cells that detect odors, according to an animal study in the September 28 issue of The Journal of Neuroscience. The findings shed light on why people with Alzheimer's disease often lose their sense of smell early on in the course of the disease. "Deficits in odor detection and discrimination are among the earliest symptoms of Alzheimer's disease, suggesting that the sense of...

2011-09-19 05:23:56

(Ivanhoe Newswire) -- High cholesterol may be clogging more than just the heart.  In a recent study, people with high cholesterol may have a higher risk of developing Alzheimer's disease. "We found that high, cholesterol levels were significantly related to brain plaques associated with Alzheimer's disease," study author, Kensuke Sasaki, MD, Ph.D, of Kyushu University of Fukoka, Japan, was quoted as saying. The cholesterol levels were tested for 2,587 people between the ages of 40...

2011-09-07 19:35:01

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that causes progressive cognitive impairment and memory loss. Now, a new study published by Cell Press in the September 8 issue of the journal Neuron identifies a previously unrecognized link between neuroinflammation and the classical pathological brain changes that are the hallmark of the disease. In addition, the research identifies a new potential therapeutic target for AD. AD is characterized by abnormal accumulation...

2011-09-01 16:37:55

Alzheimer disease (AD) is the most common cause of dementia among older people. One of the main features of AD is the presence in the brain of abnormal clumps of the protein fragment beta-amyloid, which are known as amyloid plaques. A team of researchers, led by Jens Pahnke, at the University of Rostock, Germany, has now identified a way to reduce the amount of beta-amyloid in the brains of mice with a disease that models AD, providing hope that a similar approach might be possible in...

2011-09-01 15:24:41

Researchers have found that a protein variation linked by some genetic studies to Alzheimer's disease is consistently present in the brains of people with Alzheimer's. In further biochemical and cell culture investigations, they have shown that this protein, known as ubiquilin-1, performs a critical Alzheimer's-related function: it "chaperones" the formation of amyloid precursor protein, a molecule whose malformation has been directly tied to Alzheimer's pathology. "What we saw here is...

2011-08-29 12:04:04

Preventing the formation of amyloid fibrils A molecule which can stop the formation of long protein strands, known as amyloid fibrils, that cause joint pain in kidney dialysis patients has been identified by researchers at the University of Leeds. The discovery could lead to new methods to identify drugs to prevent, treat or halt the progression of other conditions in which amyloid fibrils play a part, including Alzheimer's, Parkinson's and Type II diabetes. The research, funded by...

2011-08-25 03:34:40

A brain imaging scan identifies biochemical changes in the brains of normal people who might be at risk for Alzheimer's disease, according to research published in the August 24, 2011, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study of 311 people in their 70s and 80s with no cognitive problems, from the population-based Mayo Clinic Study of Aging, used an advanced brain imaging technique called proton MR spectroscopy to see if they had...

2011-07-19 13:17:35

A single traumatic brain injury may prompt long-term neurodegeneration, Penn study shows Years after a single traumatic brain injury (TBI), survivors still show changes in their brains. In a new study, researchers from the Perelman School of Medicine at the University of Pennsylvania suggest that Alzheimer's disease-like neurodegeneration may be initiated or accelerated following a single traumatic brain injury, even in young adults. Over 1.7 million Americans suffer a traumatic brain injury...


Word of the Day
cruet
  • A vial or small glass bottle, especially one for holding vinegar, oil, etc.; a caster for liquids.
This word is Middle English in origin, and ultimately comes from the Old French, diminutive of 'crue,' flask.
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