Latest Biochemistry of Alzheimer's disease Stories
A protein associated with Alzheimerâ€™s disease clogs several motors of the cell transport machinery critical for normal cell division, leading to defective neurons that may contribute to the memory-robbing disease.
Researchers using two brain-imaging technologies have found that apparently normal older individuals with brain deposits of amyloid beta â€“ the primary constituent of the plaques found in the brains of Alzheimer's disease patients â€“ also had changes in brain structure similar to those seen in Alzheimer's patients.
LA JOLLA, Calif., March 4, 2011 /PRNewswire/ -- Unexpected results from a Scripps Research Institute and ModGene, LLC study could completely alter scientists' ideas about Alzheimer's disease -- pointing to the liver instead of the brain as the source of the "amyloid" that deposits as brain plaques associated with this devastating condition.
Amyloid-beta and tau protein deposits in the brain are characteristic features of Alzheimer disease.
Increasing puromycin-sensitive aminopeptidase, the most abundant brain peptidase in mammals, slowed the damaging accumulation of tau proteins that are toxic to nerve cells and eventually lead to the neurofibrillary tangles, a major pathological hallmark of Alzheimer's disease and other forms of dementia.
Preliminary research suggests that use of a type of molecular imaging procedure may have the ability to detect the presence of beta-amyloid in the brains of individuals during life, a biomarker that is identified during autopsy to confirm a diagnosis of Alzheimer disease.
A Blanchette Rockefeller Neurosciences Institute (BRNI) study published today in the Journal of Neuroscience reveals underlying causes for the degeneration of synapses in Alzheimer's Disease and identifies promising pharmaceutical solutions for the devastating condition that affects more than 5 million people in the United States.
Study in Mice Indicates Disease's Underlying Causes and Finds Compounds That Normalize the Alzheimer's Brain MORGANTOWN, W.Va., Jan.
People at known high risk for Alzheimerâ€™s disease develop abnormal brain function even before the appearance of amyloid plaques that are characteristic of the disease.
People with a known, high risk for Alzheimerâ€™s disease develop abnormal brain function even before the appearance of telltale amyloid plaques that are characteristic of the disease, according to a new study.
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