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Latest Biochemistry of Alzheimer's disease Stories

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2010-09-17 15:09:03

By Jim Dryden, Washington University in St. Louis An international team of Alzheimer's disease experts, led by Washington University School of Medicine in St. Louis, has uncovered a gene variation that appears to predict the rate at which Alzheimer's disease will progress. The investigators report their findings online in the journal Public Library of Science (PLoS) Genetics. Whereas previous studies have focused on factors that influence the risk for Alzheimer's, the new research points to a...

2010-09-11 02:16:25

In people with Alzheimer's, the brain becomes riddled with clumps of protein, forming what are known as amyloid plaques. Now, a report appearing in the September 17th print issue of Cell appears to have found a function for the amyloid precursor protein (APP for short) that yields the prime ingredient in those plaques. It turns out that APP is an iron oxidase whose job it is to convert iron from an unsafe form to a safe one for transport or storage. When APP fails to function properly, as it...

2010-09-09 01:10:08

A team of scientists, led by University of California, San Diego School of Medicine researchers, has synthesized hundreds of new compounds with the potential of reducing the production of the A-beta 42 peptide, a primary component of Alzheimer's disease (AD). In mouse models, one tested compound specifically reduced levels of A-beta 42, which is believed to be responsible for the destruction of neurons, but left other essential enzymatic activities in the brain unaffected, said Steven Wagner,...

2010-09-09 01:09:20

Data published in Neuron demonstrate proof of concept in long term prevention of disease pathology in a mouse model, without GI side effects In the Sept 9, 2010 issue of Neuron, Neurogenetic Pharmaceuticals, Inc. (NGP) reports proof of concept studies that show its proprietary compound, NGP 555, is effective in preventing the amyloid pathology of Alzheimer's disease (AD) in a transgenic mouse model. The study further demonstrates that following chronic treatment with the gamma secretase...

2010-08-10 13:43:21

High plasma levels of beta-amyloid"”protein fragments associated with Alzheimer's disease when they accumulate in the brain"”appear to be associated with faster cognitive decline even in those who do not develop dementia, according to a report posted online today that will appear in the December print issue of Archives of Neurology, one of the JAMA/Archives journals. The amyloid cascade hypothesis suggests that Alzheimer's disease develops when the body is unable to metabolize...

2010-07-06 12:27:05

Higher concentrations of clusterin, a protein in the blood plasma, appears to be associated with the development, severity and progression of Alzheimer's disease, according to a report in the June issue of Archives of General Psychiatry, one of the JAMA/Archives journals. Individuals with Alzheimer's disease display several findings in their blood and cerebrospinal fluid that may reflect neuropathological changes, according to background information in the article. For instance, in...

2010-06-25 16:20:57

Scientists discovered characteristic amyloid plaques in retinas from Alzheimer's disease patients and used a noninvasive optical imaging technique to detect retinal plaques in live laboratory mice, suggesting the possibility of early noninvasive diagnosis The nerve cell-damaging plaque that builds up in the brain with Alzheimer's disease also builds up in the retinas of the eyes "“ and it shows up there earlier, leading to the prospect that noninvasive optical imaging of the eyes could...

2010-06-08 11:36:33

Recent study documents the spread of a disease process thought to signal the onset of Alzheimer's disease Research unveiled at SNM's 57th Annual Meeting shows that scientists are drawing closer to documenting the progression of a disease process believed to cause Alzheimer's disease. This research could eventually lead to life-saving preventative measures for millions of patients who suffer from this chronic neurodegenerative disorder. "Alzheimer's is a relentless disease that kills once it...

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2010-04-20 13:14:48

Researchers at the University of Illinois have identified a potential drug target for the treatment of Alzheimer's disease: a receptor that is embedded in the membrane of neurons and other cells. A protein fragment associated with Alzheimer's disease activates this receptor, sparking increased activity in the affected neurons, eventually leading to cell death, the researchers report. The new findings appear in the FASEB Journal. Scientists have known for decades that a protein fragment,...

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2010-04-16 13:04:52

A major Australian study has provided new insights into the loss of structure in regions of the brain and its potential association with Alzheimer's Disease. The findings recently reported in Neurology suggest a build-up of deposits of the protein amyloid-beta in a region of the brain known as the temporal inferior cortex. The region is connected to the hippocampus, which is involved in memory. Alzheimer's is characterized by two factors: a build-up of amyloid-beta plaques in the brain, and a...


Word of the Day
bibliopole
  • A bookseller; now, especially, a dealer in rare and curious books.
This word comes from a Greek phrase meaning 'book seller.'
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