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Latest Biological target Stories

2014-09-18 12:27:56

LONDON, Sept. 18, 2014 /PRNewswire/ -- This report gives you a new and unique way of stratifying and analyzing the global melanoma pipeline and presents actionable analysis which allows you to discover:* Where the competition is; Which targets and companies are setting the path?* What is first-in-class in the melanoma pipeline?* Is First-in-Class the Best-in-Class?* Indication expansion opportunities* Drug repositioning opportunities* Which pathways are targeted, by what and how?*...

2014-04-30 12:31:18

Structures of human P2Y12 receptor key to next generation of antithrombotic drugs SHANGHAI, April 30, 2014 /PRNewswire/ -- An international team led by scientists at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences (SIMM) has found the detailed structure of a receptor that plays a key role in platelet activation and blood clotting. The work has implications for treatment of cardiovascular and other diseases. In a pair of papers published by the journal Nature on...

2012-01-19 15:13:40

A receptor found on blood platelets whose importance as a potential pharmaceutical target has long been questioned may in fact be fruitful in drug testing, according to new research from Michigan State University chemists. A team led by Dana Spence of MSU's Department of Chemistry has revealed a way to isolate and test the receptor known as P2X1. By creating a new, simple method to study it after blood is drawn, the team has unlocked a potential new drug target for many diseases that...

2011-04-29 14:02:11

Use of chemical systems biology may represent the future of drug discovery Researchers at the University of California, San Diego and Hunter College of the City University of New York (CUNY) have identified potential human molecular targets of the anti-HIV drug Nelfinavir, which may explain why the drug is also effective as a cancer therapy. Their study will be published in the online edition of PLoS Computational Biology on April 28. Nelfinivir is a protease inhibitor that prevents...

2011-04-29 13:34:53

Potential molecular targets of the anti-HIV drug nelfinavir have been identified, and may explain why the drug is also effective as a cancer therapy. Findings will be published in the open-access journal PLoS Computational Biology on 28th April 2011. Nelfinavir is a protease inhibitor that prevents replication of the HIV virus. It has also been found to have a positive effect on a number of solid tumor types but the mechanism of how the drug worked in humans was unclear. Researchers from the...

2011-04-01 15:26:04

Avila scientists publish 'The Resurgence of Covalent Drugs' in Nature Reviews Drug Discovery; publication recognizes the potential of rational covalent drug design to expand the breadth of therapeutic use of targeted covalent drugs Avila Therapeuticsâ“ž¢, Inc., a biotechnology company developing novel targeted covalent drugs, today announced the publication of a scientific review article in Nature Reviews Drug Discovery titled "The Resurgence of Covalent Drugs"...

2010-11-29 12:48:15

Publication in Nature Chemical Biology demonstrates that irreversible covalent inhibition can increase selectivity, potency and duration of action, broadens applications for targeted covalent drugs to the protease gene family Avila Therapeuticsâ“ž¢, Inc., a biotechnology company developing novel targeted covalent drugs, has published research in Nature Chemical Biology demonstrating the first-ever selective irreversible inhibition of a viral protease using a...

2010-04-26 07:11:56

Studies led by Stony Brook University professor of chemistry Peter J. Tonge indicate that modifications that enhance the time a drug remains bound to its target, or residence time, may lead to better diagnostic and therapeutic agents. Tonge presented these results at the American Society for Biochemistry and Molecular Biology's annual meeting in a talk titled "Slow Onset Inhibitors of Bacterial Fatty Acid Biosynthesis: Residence Time, In Vivo Activity and In Vivo Imaging." The talk was held...


Word of the Day
negawatt
  • A unit of saved energy.
Coined by Amory Lovins, chairman of the Rocky Mountain Institute as a contraction of negative watt on the model of similar compounds like megawatt.