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Latest Biomolecules Stories

2008-09-11 15:00:11

Marauding molecules cause the tissue damage that underlies heart attacks, sunburn, Alzheimer's and hangovers. But scientists at the Stanford University School of Medicine say they may have found ways to combat the carnage after discovering an important cog in the body's molecular detoxification machinery. The culprit molecules are oxygen byproducts called free radicals. These highly unstable molecules start chain reactions of cellular damage -- an escalating storm that ravages healthy...

2008-09-11 03:00:19

By Manian, Avinash P Lenninger, Margit; Bechtold, Thomas; Steinlechner, Erik Abstract The liming propensity of a woven cellulosic substrate is investigated as a function of substrate characteristics and of different parameters in the test environment. The results from the linting propensity tests parallel those observed in liquid-solid extraction processes, where solutes are extracted from a matrix of other insoluble solids by selective dissolution in a liquid. The equation quantifying...

2008-08-20 12:00:27

U.S.-led researchers say they have created a new model of catalyst design that challenges current ideas about how catalysts function. The study also suggests a method for designing new catalysts. "Catalysts are molecules that speed up chemical reactions without participating in them," the researchers said, noting thousands of industrial and biological processes rely on catalysts. In the human body, enzymes catalyze nearly every reaction. "The Holy Grail of enzyme catalysis and the...

2008-08-06 12:00:00

University of Georgia researchers suggest herbs and spices are potent inhibitors of tissue damage and inflammation caused by high levels of blood sugar. Study co-author James Hargrove said that when blood sugar levels are high, a process known as protein glycation occurs in which the sugar bonds with proteins to eventually form what are known as advanced glycation end products, known as AGE compounds. These compounds activate the immune system, resulting in the inflammation and tissue damage...

2008-07-25 03:00:40

By Kubiak, Karina Nowak, Wieslaw ABSTRACT Nitrile hydratase (NHase) is an enzyme used in the industrial biotechnological production of acrylamide. The active site, which contains nonheme iron or noncorrin cobalt, is buried in the protein core at the interface of two domains, alpha and beta. Hydrogen bonds between betaArg-56 and alphaCys-114 sulfenic acid (alphaCEA114) are important to maintain the enzymatic activity. The enzyme may be inactivated by endogenous nitric oxide (NO) and...

2008-07-07 15:00:13

U.S. scientists say they have produced synthetic molecules that can emulate enzyme behaviors. Many jobs require highly specialized catalysts and finding one in just the right shape to connect with certain molecules can be difficult, the Ohio State University chemists said, noting enzymes in the human body that help us digest food can utilize shape-shifting to suit the task at hand. Now the Ohio State researchers say they have created a synthetic catalyst that can fold its molecular...

2008-07-02 16:14:38

COLUMBUS, Ohio -- When chemists want to produce a lot of a substance -- such as a newly designed drug -- they often turn to catalysts, molecules that speed chemical reactions. Many jobs require highly specialized catalysts, and finding one in just the right shape to connect with certain molecules can be difficult.  Natural catalysts, such as enzymes in the human body that help us digest food, get around this problem by shape-shifting to suit the task at hand. Chemists have made little...

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2008-03-24 14:15:00

Scientists succeed in designing artificial enzymes that also undergo 'evolution in a test tube'Mankind triumphed in a recent 'competition' against nature when scientists succeeded in creating a new type of enzyme for a reaction for which no naturally occurring enzyme has evolved. This achievement opens the door to the development of a variety of potential applications in medicine and industry. Enzymes are, without a doubt, a valuable model for understanding the intricate works of nature....

2007-09-15 03:00:53

By Bengmark, Stig ABSTRACT. Background: High levels of glycated and lipoxidated proteins and peptides in the body are repeatedly associated with chronic diseases. These molecules are strongly associated with activation of a specific receptor called RAGE and a long-lasting exaggerated level of inflammation in the body. Methods: PubMed reports over 5000 papers plus > 13,500 articles about the related HbA^sub 1c^, most of them published in the past 5 years. Most of the available abstracts...

2007-06-12 03:00:10

By Masubuchi, Yasuhiro Horie, Toshiharu Cytochrome P450 (P450) enzymes oxidize xenobiotics into chemically reactive metabolites or intermediates as well as into stable metabolites. If the reactivity of the product is very high, it binds to a catalytic site or sites of the enzyme itself and inactivates it. This phenomenon is referred to as mechanism-based inactivation. Many clinically important drugs are mechanism-based inactivators that include macrolide antibiotics, calcium channel...


Word of the Day
endocarp
  • The hard inner (usually woody) layer of the pericarp of some fruits (as peaches or plums or cherries or olives) that contains the seed.
This word comes from the Greek 'endon,' in, within, plus the Greek 'kardia,' heart.
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