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Latest Biomolecules Stories

2008-08-06 12:00:00

University of Georgia researchers suggest herbs and spices are potent inhibitors of tissue damage and inflammation caused by high levels of blood sugar. Study co-author James Hargrove said that when blood sugar levels are high, a process known as protein glycation occurs in which the sugar bonds with proteins to eventually form what are known as advanced glycation end products, known as AGE compounds. These compounds activate the immune system, resulting in the inflammation and tissue damage...

2008-07-25 03:00:40

By Kubiak, Karina Nowak, Wieslaw ABSTRACT Nitrile hydratase (NHase) is an enzyme used in the industrial biotechnological production of acrylamide. The active site, which contains nonheme iron or noncorrin cobalt, is buried in the protein core at the interface of two domains, alpha and beta. Hydrogen bonds between betaArg-56 and alphaCys-114 sulfenic acid (alphaCEA114) are important to maintain the enzymatic activity. The enzyme may be inactivated by endogenous nitric oxide (NO) and...

2008-07-07 15:00:13

U.S. scientists say they have produced synthetic molecules that can emulate enzyme behaviors. Many jobs require highly specialized catalysts and finding one in just the right shape to connect with certain molecules can be difficult, the Ohio State University chemists said, noting enzymes in the human body that help us digest food can utilize shape-shifting to suit the task at hand. Now the Ohio State researchers say they have created a synthetic catalyst that can fold its molecular...

2008-07-02 16:14:38

COLUMBUS, Ohio -- When chemists want to produce a lot of a substance -- such as a newly designed drug -- they often turn to catalysts, molecules that speed chemical reactions. Many jobs require highly specialized catalysts, and finding one in just the right shape to connect with certain molecules can be difficult.  Natural catalysts, such as enzymes in the human body that help us digest food, get around this problem by shape-shifting to suit the task at hand. Chemists have made little...

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2008-03-24 14:15:00

Scientists succeed in designing artificial enzymes that also undergo 'evolution in a test tube'Mankind triumphed in a recent 'competition' against nature when scientists succeeded in creating a new type of enzyme for a reaction for which no naturally occurring enzyme has evolved. This achievement opens the door to the development of a variety of potential applications in medicine and industry. Enzymes are, without a doubt, a valuable model for understanding the intricate works of nature....

2007-09-15 03:00:53

By Bengmark, Stig ABSTRACT. Background: High levels of glycated and lipoxidated proteins and peptides in the body are repeatedly associated with chronic diseases. These molecules are strongly associated with activation of a specific receptor called RAGE and a long-lasting exaggerated level of inflammation in the body. Methods: PubMed reports over 5000 papers plus > 13,500 articles about the related HbA^sub 1c^, most of them published in the past 5 years. Most of the available abstracts...

2007-06-12 03:00:10

By Masubuchi, Yasuhiro Horie, Toshiharu Cytochrome P450 (P450) enzymes oxidize xenobiotics into chemically reactive metabolites or intermediates as well as into stable metabolites. If the reactivity of the product is very high, it binds to a catalytic site or sites of the enzyme itself and inactivates it. This phenomenon is referred to as mechanism-based inactivation. Many clinically important drugs are mechanism-based inactivators that include macrolide antibiotics, calcium channel...

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2007-03-20 08:20:00

Researchers at the University of California, Santa Cruz, have determined the three-dimensional structure of an RNA enzyme, or "ribozyme," that carries out a fundamental reaction required to make new RNA molecules. Their results provide insight into what may have been the first self-replicating molecule to arise billions of years ago on the evolutionary path toward the emergence of life. In all forms of life known today, the synthesis of DNA and RNA molecules is carried out by enzymes made of...

2007-01-07 21:00:10

By Rajen M. BLOOD purification is a very traditional medicine concept, and very prevalent in the east. Cuci darah as we call it here is common amongst all major races. The roots of the concept arise from the Indian traditonal system of healing - Ayurveda, Chinese traditional medicine and in Malay medicine. Blood is seen as the medium constantly flowing through our bodies. It supplies life giving nutrients, blood and carries away metabolic wastes. Some of these are toxins which...

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2006-08-23 08:59:08

Water, that molecule-of-all-trades, is famous for its roles in shaping the Earth, sustaining living creatures and serving as a universal solvent. Now, researchers at the University of Michigan and the Academy of Sciences of the Czech Republic have uncovered two previously unknown roles for water in RNA enzymes, molecules which themselves play critical roles in living cells and show promising medical applications. The researchers' findings will be published online in the Proceedings of the...


Word of the Day
callithump
  • A somewhat riotous parade, accompanied with the blowing of tin horns, and other discordant noises; also, a burlesque serenade; a charivari.
'Callithump' is a back-formation of 'callithumpian,' a 'fanciful formation' according to the Oxford English Dictionary. However, the English Dialect Dictionary, says 'Gallithumpians' is a Dorset and Devon word from the 1790s that refers to 'a society of radical social reformers' or 'noisy disturbers of elections and meetings.'
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