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Latest Blood disorders Stories

2012-04-19 05:15:30

(Ivanhoe Newswire) -- According to a recent study, two related enzymes, phosphoinositide-3 kinase (PI3k) gamma and delta, have been found to have a role in the development of an aggressive childhood leukemia (T-cell acute lymphoblastic leukemia (T-ALL)) that is highly difficult to treat. The study sets the stage for clinical trials by revealing that a dual PI3K gamma/delta inhibitor can prolong survival in a mouse model of the disease and the dual inhibitor can prevent proliferation and...

2012-04-16 22:25:08

Inhibiting 2 related enzymes significantly improves survival in mouse model of the disease Columbia University Medical Center (CUMC) scientists have demonstrated that two related enzymes – phosphoinositide-3 kinase (PI3K) gamma and delta – play a key role in the development of T-cell acute lymphoblastic leukemia (T-ALL), a highly aggressive childhood leukemia that is difficult to treat. The study also showed that a dual PI3K gamma/delta inhibitor can significantly prolong...

2012-04-16 11:48:23

Use of new gene-sequencing technology rapidly identifies mutations that lead to drug resistance Through a groundbreaking new gene sequencing technology, researchers have demonstrated that the gene FLT3 is a valid therapeutic target in Acute Myeloid Leukemia, AML, one of the most common types of leukemia. The technique, developed by Pacific Biosciences, allows for the rapid and comprehensive detection of gene mutations in patients with AML. The findings, published online April 15 in...

2012-04-16 11:08:31

Gene mutations play critically important role in acute myeloid leukemia -- A promising development for new treatments The key to treating one of the most common types of human leukemia may lie within mutations in a gene called FLT3, according to new research led by physician-scientists at the University of California, San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center. Published this week in the journal Nature, the work validates certain activating mutations in the...


Word of the Day
sough
  • A murmuring sound; a rushing or whistling sound, like that of the wind; a deep sigh.
  • A gentle breeze; a waft; a breath.
  • Any rumor that engages general attention.
  • A cant or whining mode of speaking, especially in preaching or praying; the chant or recitative characteristic of the old Presbyterians in Scotland.
  • To make a rushing, whistling, or sighing sound; emit a hollow murmur; murmur or sigh like the wind.
  • To breathe in or as in sleep.
  • To utter in a whining or monotonous tone.
According to the OED, from the 16th century, this word is 'almost exclusively Scots and northern dialect until adopted in general literary use in the 19th.'
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