Latest BMAL Stories

2014-04-16 10:13:27

All organisms, from mammals to fungi, have daily cycles controlled by a tightly regulated internal clock, called the circadian clock. The whole-body circadian clock, influenced by the exposure to light, dictates the wake-sleep cycle. At the cellular level, the clock is controlled by a complex network of genes and proteins that switch each other on and off based on cues from their environment. Most genes involved in the regulation of the circadian clock have been characterized, but Akihiro...

2013-12-20 10:34:33

Reprogramming of liver ‘clock’ may contribute to metabolic disorders A high-fat diet affects the molecular mechanism controlling the internal body clock that regulates metabolic functions in the liver, UC Irvine scientists have found. Disruption of these circadian rhythms may contribute to metabolic distress ailments, such as diabetes, obesity and high blood pressure. There’s good news, though. The researchers also discovered that returning to a balanced, low-fat diet normalized...

2013-04-10 10:55:21

Understanding how oncogenes affect the body clock may help create better cancer treatments The Myc oncogene can disrupt the 24-hour internal rhythm in cancer cells. Postdoctoral fellow Brian Altman, PhD, and graduate student Annie Hsieh, MD, both from the in the lab of Chi Van Dang, MD, PhD, director of the Abramson Cancer Center, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, present their data in the "Metabolic Pathway Regulation in...

2009-11-12 22:36:24

A paper by University of Notre Dame biologist Giles Duffield and a team of researchers offers new insights into a gene that plays a key role in modulating the body's Circadian system and may also simultaneously modulate its metabolic system. The relationship between circadian and metabolic systems the researchers describe could have important implications for understanding the higher incidence of cardiovascular disease, obesity and diabetes among shift workers. The master circadian clock in...

2008-08-28 03:00:22

By Saey, Tina Hesman Work could lead to drugs for obesity, aging and jet lag Cue stomach rumbles SIRT1 sets internal clock To metabolism Timing is everything, especially when it comes to basic biological functions such as eating, sleeping and liver activity. Scientists have known for ages that metabolism is tied to the body's daily rhythms but have not known how. Now, two groups of researchers report in the July 25 Cell the discovery of a molecule that links metabolism to the...

2008-05-22 14:50:00

Findings could help travelers, shift workers adjust to changes in time zones and overnight schedulesIn investigating the intricacies of the body's biological rhythms, scientists at Beth Israel Deaconess Medical Center (BIDMC) have discovered the existence of a "food-related clock" which can supersede the "light-based" master clock that serves as the body's primary timekeeper.The findings, which appear in the May 23 issue of the journal Science, help explain how animals adapt their circadian...

Word of the Day
  • Good cheer; viands.
  • To revel; to feast.
The word 'bellycheer' may come from 'belle cheer', "good cheer".