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Latest Brain-derived neurotrophic factor Stories

2012-10-11 13:05:50

Repairing brain damage a significant departure from current treatments Washington State University researchers have developed a new drug candidate that dramatically improves the cognitive function of rats with Alzheimer's-like mental impairment. Their compound, which is intended to repair brain damage that has already occurred, is a significant departure from current Alzheimer's treatments, which either slow the process of cell death or inhibit cholinesterase, an enzyme believed to...

2012-10-09 10:52:41

Deletion of brain-derived neurotrophic factor leads to major depression, anxiety, and obesity McGill researchers have identified a small region in the genome that conclusively plays a role in the development of psychiatric disease and obesity. The key lies in the genomic deletion of brain-derived neurotrophic factor, or BDNF, a nervous system growth factor that plays a critical role in brain development. To determine the role of BDNF in humans, Prof. Carl Ernst, from McGill's Department...

2012-08-15 01:16:54

Connecting the dots between two molecules whose levels are decreased in depression and increased by current antidepressants could yield new therapies, researchers say. Serotonin is a neurotransmitter that enables brain cells to communicate and brain-derived neurotropic factor, or BDNF, is a brain-nourishing molecule that also aids connectivity. Popular antidepressants such as Prozac, developed to increase levels of serotonin, have recently been found to also increase BDNF levels, said Dr....

2012-08-15 01:11:59

Researchers discover compounds in green tea and chocolate may help reduce neurological complications linked to HIV Current drug therapy for patients with HIV is unable to control the complete replication of the virus in the brain. The drugs therefore do not have any effect against the complications associated with neurocognitive impairment in patients with HIV. New research by Joseph Steiner and colleagues from Johns Hopkins University has discovered that a group of plant polyphenols...

2012-08-07 23:17:46

Biomarkers help pinpoint mechanisms, predict outcomes -- NIH studies Scientists have discovered a biological marker that may help to identify which depressed patients will respond to an experimental, rapid-acting antidepressant. The brain signal, detectable by noninvasive imaging, also holds clues to the agent's underlying mechanism, which are vital for drug development, say National Institutes of Health researchers. The signal is among the latest of several such markers, including...

2012-04-23 11:21:23

With more than 1.7 million people sustaining a traumatic brain injury each year, the need to identify processes to limit inflammation and subsequent damage is critical. Approximately 275,000 people are hospitalized annually with traumatic brain injury, leaving 85,000 with long-term disabilities and taking the lives of more than 50,000. More than 5 million people live with disabilities caused by traumatic brain injuries, often the result of car accidents and falls. Direct and indirect costs...

2012-03-23 05:43:10

(Ivanhoe Newswire)-- A ravenous appetite may be what causes many overweight people to be obese. Researchers have found a mutation in a single gene is responsible for the inability of neurons to effectively send out appetite suppressing signals from the body to the correct area of the brain. A study suggests that there might be a way to stimulate expression of that gene to treat obesity caused by uncontrolled eating. Researchers found that a mutation in the brain-derived neurotrophic...

2012-03-19 04:53:45

The discovery offers clues about how to turn on brain sensitivity to leptin and insulin, hormones that turn off appetite Researchers at Georgetown University Medical Center have revealed how a mutation in a single gene is responsible for the inability of neurons to effectively pass along appetite suppressing signals from the body to the right place in the brain. What results is obesity caused by a voracious appetite. Their study, published March 18th on Nature Medicine's website,...

2012-01-27 15:31:55

The research, published in Neuroscience, sheds light on what determines availability of the molecules involved in cardiorespiratory control Researchers at Oregon Health & Science University (http://www.ohsu.edu) have discovered that a molecule critical to the development and plasticity of nerve cells — brain-derived neurotrophic factor (BDNF) -- is severely lacking in brainstem neurons in mutations leading to Rett syndrome, a neurological developmental disorder. The finding has...

Alzheimer's Drug Candidate Could Prevent Disease Progression
2011-12-15 04:55:47

[ Watch the Video ] Salk scientists develop new drug that improves memory and prevents brain damage in mice A new drug candidate may be the first capable of halting the devastating mental decline of Alzheimer's disease, based on the findings of a study published Dec. 14 in PLoS ONE. When given to mice with Alzheimer's, the drug, known as J147, improved memory and prevented brain damage caused by the disease. The new compound, developed by scientists at the Salk Institute for...


Word of the Day
bodacious
  • Remarkable; prodigious.
  • Audacious; gutsy.
  • Completely; extremely.
  • Audaciously; boldly.
  • Impressively great in size; enormous; extraordinary.
This word is probably from the dialectal 'boldacious,' a blend of 'bold' and 'audacious.'
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