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Latest Brain-derived neurotrophic factor Stories

2011-12-08 07:57:27

(Ivanhoe Newswire) — Save the neurons! A new study suggests laquinimod triggers immune cells within the central nervous system produce and release brain-derived neurotrophic factor, BDNF, contributing to the repair or survival of neurons; therefore limiting brain damage. Laquinimod is an orally available synthetic compound for the treatment of relapsing-remitting multiple sclerosis. "Our data are indicative of a direct and sustained effect of laquinimod on the up-regulation of...

2011-12-07 22:15:33

Animal study offers insights into possible drug targets to improve memory as we age Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study in the December 7 issue of The Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults. Aging-related memory loss is associated with the gradual...

2011-12-06 11:21:42

Results published in the American Journal of Pathology Laquinimod is an orally available synthetic compound that has been successfully evaluated in phase II/III clinical studies for the treatment of relapsing-remitting multiple sclerosis (RRMS). The mechanism of action of laquinimod has not been fully elucidated, but a study published in the January 2012 issue of The American Journal of Pathology suggests that laquinimod triggers immune cells within the central nervous system to produce...

2011-10-25 11:32:47

A tiny difference in the coding pattern of a single gene significantly affects the rate at which men's intellectual function drops with advancing age, investigators at the Stanford University School of Medicine and the Veterans Affairs Palo Alto Health Care System have learned. In a study to be published online Oct. 25 in Translational Psychiatry, the researchers tested the skills of experienced airplane pilots and found that having one version of the gene versus the other version doubled...

2011-09-16 11:37:26

Researchers at the University of Pittsburgh School of Medicine have discovered molecular-level changes in the brains of women with major depressive disorder that link two hypotheses of the biological mechanisms that lead to the illness. Their results, published online this week in Molecular Psychiatry, also allowed them to recreate the changes in a mouse model that could enhance future research on depression. Although women are twice as likely as men to develop depression and have more...

2011-09-06 22:16:12

When mice are given a more engaging place to live with greater opportunities for social stimulation, some of their energy-storing white fat is transformed to energy-burning brown fat. As a result, the animals expend more energy and lose weight even as they eat more. The findings reported in the September Cell Metabolism, a Cell Press publication, point to the powerful effect that animals' social and physical environments can have on their metabolisms. "I'm still amazed at the degree of fat...

2011-08-16 12:40:26

    * Brain-derived neurotrophic factor (BDNF) regulates neuronal plasticity.    * Researchers have found high serum BDNF levels among alcohol-dependent (AD) but abstinent individuals that do not correlate with either chronic drinking or associated toxicity.    * These findings suggest that BDNF may predict relapse in AD individuals undergoing treatment. One of the ways an alcohol dependence (AD) diagnosis can be made is through measurement of...

2011-04-26 14:59:23

Brain-derived protein in colorectal cancer Tumor progression is usually ensured by more than one proliferative mechanism. When one of these is shut down by a specifically targeted drug, other mechanisms may emerge. While these events may lead to treatment failure, they may also become an opportunity for researchers to identify novel targets to be further explored. In a paper recently published in the journal Oncology ("BDNF/TrkB content and interaction with gastrin-releasing peptide receptor...

2011-04-18 21:10:16

An estimated 19 million Americans suffer from depression, and though the symptoms might be recognizable, the brain chemistry that underlies them is incompletely understood. Research suggests that aberrant signaling by a chemical called Brain-Derived Neurotrophic Factor (BDNF) through its receptor TrkB, may contribute to anxiety and depression, and inhibiting this pathway in mice can reduce anxiety and depression-related behaviors. However, translating these findings to clinical studies will...

2011-02-08 13:23:16

A new study from the Centre for Addiction and Mental Health (CAMH) has found evidence suggesting that a variation of a specific gene may play a role in late-onset Alzheimer's, the disease which accounts for over 90% of Alzheimer's cases. This innovative study has combined genetics and brain imaging to determine who may be at risk for developing late-onset Alzheimer's disease long before symptoms appear. The gene, which is called brain-derived neurotrophic factor (BDNF), is crucial to...


Word of the Day
lunula
  • A small crescent-shaped structure or marking, especially the white area at the base of a fingernail that resembles a half-moon.
This word is a diminutive of the Latin 'luna,' moon.
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