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Latest Brain-derived neurotrophic factor Stories

2010-04-20 08:22:58

Altered expression and/or function of the protein BDNF, which promotes nerve cell survival, generation, and function, have been implicated in several neurodegenerative conditions, including Alzheimer disease. Although several properties of BDNF preclude its therapeutic application, it has been suggested that molecules that stimulate the protein to which BDNF binds, TrkB, might have therapeutic potential. Now, a team of researchers, led by Frank Longo, at Stanford University School of...

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2010-03-25 10:14:20

The research, published in the journal Neuroscience, finds that a protein involved in pain signaling is boosted when tissues are inflamed Using a novel animal model to study craniofacial pain, researchers at Oregon Health & Science University's School of Dentistry have discovered that when tissues are inflamed, the nerve cells carrying pain information from the head to the brain produce in large quantities a protein involved in pain signaling. The finding could play a significant role in...

2010-03-12 09:20:53

The research, published in the Journal of Neuroscience Research, sheds light on what determines availability of the molecules involved in blood pressure control Researchers at Oregon Health & Science University's School of Dentistry have discovered that nitric oxide is a powerful regulator of a molecule that plays a critical role in the development and function of the nervous system. The finding could someday play a significant role in the prevention and treatment of high blood pressure,...

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2010-03-03 07:41:25

Study suggests mental activity could stave off age-related cognitive and memory decline UC Irvine neurobiologists are providing the first visual evidence that learning promotes brain health "” and, therefore, that mental stimulation could limit the debilitating effects of aging on memory and the mind. Using a novel visualization technique they devised to study memory, a research team led by Lulu Chen and Christine Gall found that everyday forms of learning animate neuron receptors that...

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2010-02-09 15:10:00

Gene changes how mice respond to natural flux of hormones in their estrous cycle Scientists have identified a gene they say is a strong candidate for involvement in premenstrual dysphoric disorder (PMDD) and other maladies associated with the natural flux in hormones during the menstrual cycle. In a paper published Monday in the Proceedings of the National Academy of Sciences, Rockefeller University researchers detail experiments in mice showing that a common human variant of the gene...

2010-02-04 22:16:08

Scientists at Emory University School of Medicine have discovered unexpected properties for a precursor to melatonin, the hormone that regulates sleep cycles. Melatonin is produced from the neurotransmitter serotonin in a daily rhythm that peaks at night. Melatonin's immediate precursor, N-acetylserotonin, was not previously thought to have effects separate from those of melatonin or serotonin. Now an Emory team has shown that N-acetylserotonin can stimulate the same circuits in the brain...

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2010-01-27 14:41:56

Draw a map of the brain when fear and anxiety are involved, and the amygdala"”the brain's almond-shaped center for panic and fight-or-flight responses"”looms large. But the amygdala doesn't do its job alone. Scientists at Emory University have recently built upon work from others, extending the fear map to part of the brain known as the prelimbic cortex. Researchers led by Kerry Ressler, MD, PhD, found that mice lacking a critical growth factor in the prelimbic cortex have trouble...

2010-01-26 12:16:21

Researchers have identified a compound that mimics one of the brain's own growth factors and can protect brain cells against damage in several animal models of neurological disease. 7,8-dihydroxyflavone is a member of the flavonoid family of chemicals, which are abundant in fruits and vegetables. The compound's selective effects suggest that it could be the founder of a new class of brain-protecting drugs. The results were published online this week in the Proceedings of the National Academy...

2010-01-20 13:37:06

2 major studies in 2 months make a new case for an old suspect in the mystery of how memory works A second high-profile paper in as many months has found an important role in learning and memory for calpain, a molecule whose academic fortunes have ebbed and flowed for 25 years. USC's Michel Baudry (then at the University of California, Irvine) and Gary Lynch (UC Irvine) first pointed to calpain as the key to memory in a seminal 1984 paper in Science on the biochemistry of memory. In a paper...

2010-01-14 20:27:32

Mice and humans with same human gene abnormality behave similarly according to study in journal Science Studying animals in behavioral experiments has been a cornerstone of psychological research, but whether the observations are relevant for human behavior has been unclear. Weill Cornell Medical College researchers have identified an alteration to the DNA of a gene that imparts similar anxiety-related behavior in both humans and mice, demonstrating that laboratory animals can be accurately...


Word of the Day
tessitura
  • The prevailing range of a vocal or instrumental part, within which most of the tones lie.
This word is Italian in origin and comes from the Latin 'textura,' web, structure.