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Latest BRCA1 Stories

2011-12-12 13:25:40

Women who inherit the cancer genes BRCA1 or BRCA2 from their paternal lineage may get a diagnosis a decade earlier than those women who carry the cancer genes from their mother and her ancestors, according to a new study by researchers at the North Shore-LIJ Health System's Monter Cancer Center in Lake Success, NY. The findings were reported on Thursday, Dec. 8, at the San Antonio Breast Cancer Symposium. Iuliana Shapira, MD, North director of cancer genetics, and her colleagues conducted...

2011-11-16 07:22:50

An international study describes a fundamental molecular mechanism in the development of breast cell epithelium that is altered in some breast cancer patients About 10% of breast cancers are due to mutations in genes called BRCA1 and BRCA2. However, the molecular mechanism by which alteration of these genes greatly increases the risk of cancer is not fully understood. In a new study, published Nov. 15 in the online, open-access journal PLoS Biology, an international team led by Miquel...

2011-11-01 05:57:36

(Ivanhoe Newswire) — The largest study of its kind shows that women related to a patient with breast cancer caused by a hereditary mutation, but who don´t have the mutation themselves, have no higher risk of developing cancer than relatives of patients with other types of breast cancer. This contradicts previous research conducted four years ago that said that a familial BRCA mutation in and of itself was a risk factor. "The results are encouraging and reassuring," Allison...

2011-10-26 00:37:54

The study used a quick, accurate genome sequencing method that could become a single test to screen for a broad range of cancers More patients with ovarian carcinoma carry cancer-predisposing mutations, and in more genes, than previously thought. A rapid experimental method for screening genomes has located mutations in 12 genes for inherited cancers of the ovary, fallopian tubes and peritoneum (the thin tissue lining the lower abdomen). More than one-fifth of ovarian cancers arise...

2011-10-12 10:40:04

DNA-damaging platinum drugs work better against them; BRCA1 variations have no effect Women with high-grade ovarian cancer live longer and respond better to platinum-based chemotherapy when their tumors have BRCA2 genetic mutations, researchers at The University of Texas MD Anderson Cancer Center and the Institute for Systems Biology report in the Oct. 12 issue of the Journal of the American Medical Association. "BRCA2-mutated tumors are more vulnerable to these DNA-damaging agents,...

2011-10-12 10:35:42

Among women with a certain type of high-grade ovarian cancer, having BRCA2 genetic mutations, but not BRCA1, was associated with improved overall survival and improved response to chemotherapy, compared to women with BRCA wild-type (genetic type used as a reference to compare genetic mutations), according to a study in the October 12 issue of JAMA. "Increased surveillance of BRCA1/2 germ line mutation carriers is a generally accepted strategy for detecting early ovarian cancer. Women with...

2011-09-01 15:32:02

It is widely known that mutations in the breast cancer susceptibility 1 (BRCA1) gene significantly increase the chance of developing breast and ovarian cancers, but the mechanisms at play are not fully understood. Now, researchers at Virginia Commonwealth University Massey Cancer Center have shown that certain BRCA1 mutations result in excessive, uncontrolled DNA repair, which challenges the prior assumption that mutations in BRCA1 only contribute to breast cancer through a reduction in...

2011-08-03 14:30:50

Era of Hope conference to feature novel studies that address how ethnicity and inherited genes cause breast cancer -- best approaches to prevention and treatment A woman's ethnicity as well as her genetic makeup are two of the main risk factors for hereditary breast cancer. Research into understanding and treating hereditary breast cancer will be presented today at the Era of Hope conference, a scientific meeting hosted by the Department of Defense Breast Cancer Research Program (BCRP)....

2011-06-30 13:41:10

Researchers at Dana-Farber Cancer Institute have demonstrated a molecular strategy they say could make a much larger variety of tumors treatable with PARP inhibitors, a promising new class of cancer drugs. Currently, the role of PARP inhibitors has mainly been restricted to cancers whose cells lack functioning versions of the damage-repair proteins BRCA1 or BRCA2 -- chiefly certain breast and ovarian cancers. In a paper published online by Nature Medicine, Geoffrey Shapiro, MD, and colleagues...

2011-06-30 13:32:10

The genome of the most common form of ovarian cancer is characterized by a few common gene mutations but also surprisingly frequent structural changes in the genome itself, said members of The Cancer Genome Atlas, including the Baylor College of Medicine Human Genome Sequencing Center, that sequenced and analyzed more than 300 such tumors. The study was the first to achieve an overview of this type of ovarian cancer. "We found that ovarian cancer has a dramatic pattern of genomic disruption,"...


Word of the Day
barratry
  • The offense of persistently instigating lawsuits, typically groundless ones.
  • An unlawful breach of duty on the part of a ship's master or crew resulting in injury to the ship's owner.
  • Sale or purchase of positions in church or state.
This word ultimately comes from the Old French word 'barater,' to cheat.
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