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Latest BRCA1 Stories

2011-02-10 08:29:50

(Ivanhoe Newswire) -- Unfortunately, some people are destined for breast cancer. According to this study, people who inherit a particular family of mutations have a high risk of develoing a very aggressive form of breast cancer. Breast tissue cells from these individuals make abnormal cell-fate decision even before cancer develops. There are many forms of human breast cancer. Mutations in the BRCA1 tumor suppressor gene are associated with the development of the "basal-like" subtype of breast...

2011-02-03 23:58:50

A new study sheds light on why individuals who inherit a particular family of mutations have a high risk of developing a very aggressive form of breast cancer. The research, published by Cell Press on February 4th in the journal Cell Stem Cell, shows that breast tissue cells from these individuals make abnormal cell-fate decisions even before cancer develops and provides exciting new insights into the mechanisms behind one of the most lethal types of breast cancer. There are many forms of...

2011-01-12 18:23:32

Better physician education and consultation with genetics professionals when recommending genetic testing for healthy relatives of cancer patients could lower costs and increase the value of the testing, said a cancer geneticist from the NCI-designated Dan L. Duncan Cancer Center at Baylor College of Medicine, who surveyed physicians to determine their level of knowledge. "In the last several years, we have noticed an increase in referrals from physicians ordering comprehensive genetic tests...

2010-11-18 13:09:57

A new drug that targets proteins responsible for helping cancer cells to repair damage to their DNA has shown promising anti-tumour activity in its first trial in humans. Some patients with a range of solid tumours, many of whom had been treated unsuccessfully for their cancer with other therapies, have seen their tumours shrink or stabilise for periods of between 46 days to more than a year. The research will be presented at the 22nd EORTC-NCI-AACR [1] Symposium on Molecular Targets and...

2010-11-10 14:14:15

An Australian research team from the Peter MacCallum Cancer Centre, the University of Melbourne and the University of Queensland has identified a new risk factor for developing breast cancer. This has been published online in the journal Cancer Prevention Research. The risk factor involves a modification (DNA methylation) to the BRCA1 gene. BRCA1 is known for its involvement in breast and ovarian cancer. Women with mutations in this gene, which inactivates its function, are predisposed to...

2010-10-29 18:46:19

An international study led by researchers at Memorial Sloan-Kettering Cancer Center has identified genetic variants in women with BRCA2 mutations that may increase or decrease their risk of developing breast cancer. The study was published today online in the open-access journal PLoS Genetics. The findings of the study suggest that genetic variants on chromosomes 10 and 20 may modify risk for breast cancer among women with a BRCA2 mutation. Researchers analyzed DNA samples from 6,272 women...

2010-10-28 08:13:51

(Ivanhoe Newswire) -- When you go to a new doctor and fill out your family history, beware! Seems paternal history is just as important as maternal history. About 5% of breast and ovarian cancer cases are the result of an inherited genetic predisposition mostly caused by the BRCA1 or BRCA2 genes. These gene mutations increase the risk of cancers in both men and women. But despite both men and women being equally likely to pass this genetic susceptibility to their children, a father's family...

2010-10-05 07:30:00

CAMBRIDGE, Mass., Oct. 5 /PRNewswire/ -- Knome, Inc. today announced the winners of its inaugural KnomeDISCOVERY Awards, a program designed to spur new genetic insights into health. Researchers Judith Conroy (University College Dublin, Ireland), Eitan Friedman (Sheba Medical Center, Israel), and Abhimanyu Garg (University of Texas-Southwestern Medical Center, USA) have been awarded KnomeDISCOVERY(TM) exome sequencing and comparative analysis packages. Each winner will use Knome's...

2010-09-20 18:50:44

Individuals with disrupting mutations in the BRCA1 gene are known to be at substantially increased risk of breast cancer throughout their lives. Now, discoveries from an international research team led by Mayo Clinic researchers show that some of those persons may possess additional genetic variants that modify their risk. These new findings enhancing individualized medicine appear in the current Nature Genetics. "These findings should be useful in helping determine individual risk for breast...

2010-09-20 18:46:39

An international consortium of scientists has discovered new genetic variants in five regions of the genome that affect the risk of ovarian cancer in the general population, according to two separate studies published today (Sunday), online in Nature Genetics. The consortium, including scientists from the U.S., Europe, Canada and Australia, based the new work on their earlier research comparing 10,283 women with ovarian cancer to 13,185 women without the disease. That effort had found a...


Word of the Day
mundungus
  • A stinking tobacco.
  • Offal; waste animal product; organic matter unfit for consumption.
This word comes from the Spanish 'mondongo,' tripe, entrails.