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Latest BRCA2 Stories

2011-11-16 07:22:50

An international study describes a fundamental molecular mechanism in the development of breast cell epithelium that is altered in some breast cancer patients About 10% of breast cancers are due to mutations in genes called BRCA1 and BRCA2. However, the molecular mechanism by which alteration of these genes greatly increases the risk of cancer is not fully understood. In a new study, published Nov. 15 in the online, open-access journal PLoS Biology, an international team led by Miquel...

2011-11-01 05:57:36

(Ivanhoe Newswire) — The largest study of its kind shows that women related to a patient with breast cancer caused by a hereditary mutation, but who don´t have the mutation themselves, have no higher risk of developing cancer than relatives of patients with other types of breast cancer. This contradicts previous research conducted four years ago that said that a familial BRCA mutation in and of itself was a risk factor. "The results are encouraging and reassuring," Allison...

2011-10-12 10:40:04

DNA-damaging platinum drugs work better against them; BRCA1 variations have no effect Women with high-grade ovarian cancer live longer and respond better to platinum-based chemotherapy when their tumors have BRCA2 genetic mutations, researchers at The University of Texas MD Anderson Cancer Center and the Institute for Systems Biology report in the Oct. 12 issue of the Journal of the American Medical Association. "BRCA2-mutated tumors are more vulnerable to these DNA-damaging agents,...

2011-10-12 10:35:42

Among women with a certain type of high-grade ovarian cancer, having BRCA2 genetic mutations, but not BRCA1, was associated with improved overall survival and improved response to chemotherapy, compared to women with BRCA wild-type (genetic type used as a reference to compare genetic mutations), according to a study in the October 12 issue of JAMA. "Increased surveillance of BRCA1/2 germ line mutation carriers is a generally accepted strategy for detecting early ovarian cancer. Women with...

2011-04-04 19:37:00

Women with ovarian cancer who have the BRCA2 gene mutation are more likely to survive the malignancy than women with the BRCA1 mutation, or women without either mutation. In results presented at the AACR 102nd Annual Meeting 2011, held April 2-6, Kelly Bolton, a fellow at the National Cancer Institute, said the findings describe the effect of these mutations in ovarian cancer survival. "There was some previous evidence that women with ovarian cancer who have mutations in the BRCA genes show...

2011-02-18 16:32:47

Between 5 % and 10 % of breast cancer cases are hereditary, arising because the patient inherits from the father or mother a mutation in a gene that is susceptible to causing the illness. BRCA1 and BRCA2 have already been identified as two of the genes to be monitored. It is estimated that 30 % of hereditary breast cancer cases are due to mutations in one of these two genes (which suggests, at the same time, that there are other genes involved, but exactly how is still unknown). In any case,...

2010-10-29 18:46:19

An international study led by researchers at Memorial Sloan-Kettering Cancer Center has identified genetic variants in women with BRCA2 mutations that may increase or decrease their risk of developing breast cancer. The study was published today online in the open-access journal PLoS Genetics. The findings of the study suggest that genetic variants on chromosomes 10 and 20 may modify risk for breast cancer among women with a BRCA2 mutation. Researchers analyzed DNA samples from 6,272 women...

2010-10-28 08:13:51

(Ivanhoe Newswire) -- When you go to a new doctor and fill out your family history, beware! Seems paternal history is just as important as maternal history. About 5% of breast and ovarian cancer cases are the result of an inherited genetic predisposition mostly caused by the BRCA1 or BRCA2 genes. These gene mutations increase the risk of cancers in both men and women. But despite both men and women being equally likely to pass this genetic susceptibility to their children, a father's family...

2010-09-01 14:21:19

Women at increased risk of breast and ovarian cancer because of inherited mutations of the BRCA1 or BRCA2 genes who had prophylactic mastectomy or salpingo-oophorectomy (removal of the fallopian tubes and ovaries) had an associated decreased risk of breast cancer and ovarian cancer, according to a study in the September 1 issue of JAMA. "Women who have inherited mutations in the BRCA1 or BRCA2 (BRCA1/2) genes have substantially elevated risks of breast cancer and ovarian cancer, with a...

2010-07-06 12:11:05

New strategy holds promise for fewer patient side effects A novel therapy designed to attack tumors in patients with a genetic mutation in either BRCA1 or BRCA2, slowed tumor growth in 85 percent of advanced breast cancer patients treated in a small study, researchers report in the July 6 issue of the Lancet. "That is really an enormous response rate in a population of patients who have received a median of three prior therapies," says study co-author Susan M. Domchek, MD, associate professor...


Word of the Day
cruet
  • A vial or small glass bottle, especially one for holding vinegar, oil, etc.; a caster for liquids.
This word is Middle English in origin, and ultimately comes from the Old French, diminutive of 'crue,' flask.
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