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Latest Breast cancer metastasis Stories

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2009-04-08 11:04:13

Researchers in Heidelberg discover new protein that is suppressed in particularly aggressive cancer cells / Article in Nature Cell Biology If cancer cells lack a certain protein, it could be much easier for them to penetrate healthy body tissue, the first step towards forming metastases. Scientists at the Pharmacology Institute of the University of Heidelberg have discovered the previously unknown cell signal factor SCAI (suppressor of cancer cell invasion), which inhibits the movement and...

2009-04-02 10:57:45

New research from UC Davis Cancer Center shows that a protein called Muc4 may be the essential ingredient that allows breast cancer to spread to other organs and resist therapeutic treatment. The study, which appears in the April 1 issue of Cancer Research, is one of the first to characterize the role of Muc4 in the disease.Kermit Carraway, senior author of the study, knew that Muc4 was not always expressed in primary breast cancer tumors, yet it could be present in lymph node metastases. He...

2009-03-27 22:08:30

U.S. researchers say they've identified a marker that could lead to a test to identify the likelihood of breast cancer metastasis. New York-Presbyterian Hospital/Weill Cornell Medical Center said the marker Tumor Microenvironment of Metastasis is associated with the development of distant organ metastasis through the bloodstream, which is the most common cause of death from breast cancer. An estimated 40 percent of breast cancer patients relapse and develop metastatic disease, the university...

2009-03-26 10:08:49

A team of 24 researchers from the U.S., Europe, Taiwan and Japan and led by University of Illinois scientists has engineered a new anti-cancer agent that is about 200 times more active in killing tumor cells than similar drugs used in recent clinical trials.The study appears this week in the Journal of the American Chemical Society.The new agent belongs to a class of drugs called bisphosphonates. These compounds were originally developed to treat osteoporosis and other bone diseases, but were...

2009-03-25 08:05:03

 Scientists at Albert Einstein College of Medicine of Yeshiva University have previously shown that the co-mingling of three cell types can predict whether localized breast cancer will spread throughout the body. Now, a collaborative study led by investigators at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, has produced a test for metastasis that could help doctors precisely identify which patients should receive aggressive therapy. This might spare many women at low risk...

2009-03-19 09:43:40

Research conducted by Allison Berrier, PhD, Assistant Professor of Oral and Craniofacial Biology at the LSU Health Sciences Center New Orleans School of Dentistry, and colleagues, provides insights that may help scientists design novel approaches to control wound healing and fight diseases such as cancer and fibrosis. The paper, ÃŽ²1 Integrin Cytoplasmic Domain Residues Selectively Modulate Fibronectin Matrix Assembly and Cell Spreading through Talin and Akt-1, will be...

2009-02-10 08:58:46

Scientists have long wondered how melanoma cells travel from primary tumors on the surface of the skin to the brain, liver and lungs, where they become more aggressive, resistant to therapy, and deadly. Now, scientists from NYU Langone Medical Center have identified the possible culprit"”a short strand of RNA called microRNA (miRNA) that is over-expressed in metastatic melanoma cell lines and tissues.The new findings, published online this week and in the February 10, 2009 print edition...

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2009-02-09 12:50:43

Japanese scientists have reported discovering an enzyme that may suppress breast cancer cells and inhibit growth. Writing in the journal Nature Cell Biology, scientists found that an enzyme called CHIP successfully suppressed breast cancer in mice. Two kinds of human breast cancer cells were injected into mice "“ one carried the CHIP enzyme and the other did not. Scientists noted that tumors were far smaller among those who had been injected with the set carrying the CHIP enzyme....

2009-02-03 16:55:57

A new study suggests that Capn4, a protein involved in cell migration, is associated with liver cancer recurrence and metastasis after liver transplantation. Capn4 could potentially be used as a biomarker for diagnosis and a target for therapy. These findings are in the February issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases (AASLD). The article is also available online at Wiley Interscience...

2009-02-02 09:05:10

Study finds Snail1 may spur cancer cells by stimulating tissue invasion and angiogenesisA transcription factor known to drive the formation of fibroblasts during development also promotes their ability to invade and remodel surrounding tissues, report Rowe et al. in the February 9, 2009 issue of the Journal of Cell Biology.The conversion of epithelial cells into fibroblast-like mesenchymal cells is a critical event in both normal development and cancer. The transcription factor Snail1 induces...