Latest Breast cancer metastasis Stories
Researchers at the Cleveland Clinic report the identification of a protein that is highly expressed in a subgroup of glioblastoma brain tumor cells and show that depletion of this protein increases the survival of mice with these tumors.
The enzyme heparanase plays a critical role in the spread of breast cancer cells to the brain, and, as such, is a promising target for future treatment, said researchers from Baylor College of Medicine and the University of California â€“ Los Angeles, in a report in the current issue of the American Association of Cancer Research journal Molecular Cancer Research.
Cancer progression is commonly thought of as a process involving the growth of a primary tumor followed by metastasis, in which cancer cells leave the primary tumor and spread to distant organs.
Up to 25% of cancer patients develop metastases in the brain â€“ often long after successful treatment of the primary tumor.
UT Southwestern Medical Center researchers have found that a naturally occurring protein â€” transforming growth factor beta1 (TGF-ÃŸ1) â€” which normally suppresses the growth of cancer cells, causes a rebound effect after a prolonged exposure.
Findings suggest treatments should take the 'soil' away from the cancer 'seed'.
Researchers have reduced breast cancer metastasis to bone using an experimental agent to inhibit ROCK, a protein that was found to be over-expressed in metastatic breast cancer.
Metastases are responsible for over 90% of cancer deaths. In the upcoming issue of G&D, Dr. Robert Weinberg (MIT) and colleagues lend molecular insight into how microRNAs suppress tumor metastasis.
Researchers at The Wistar Institute have identified a key gene (KLF17) involved in the spread of breast cancer throughout the body.
Scientists at the Burnham Institute for Medical Research in California say they've discovered reactive oxygen plays a key role in cancer metastasis. The researchers, led by Professor Sara Courtneidge, said they determined reactive species, such as superoxide and hydrogen peroxide, help form invadopodia -- cellular protrusions implicated in cancer cell migration.
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