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Latest Breast cancer metastasis Stories

2010-02-23 10:16:07

Researchers at the Cleveland Clinic report the identification of a protein that is highly expressed in a subgroup of glioblastoma brain tumor cells and show that depletion of this protein increases the survival of mice with these tumors. This work will be published in the online open-access journal PLoS Biology. Recent studies have increased our understanding of cancer by elucidating some of the differences that exist between tumor cells among patients and even between distinct subsets of...

2010-02-18 08:55:20

The enzyme heparanase plays a critical role in the spread of breast cancer cells to the brain, and, as such, is a promising target for future treatment, said researchers from Baylor College of Medicine and the University of California "“ Los Angeles, in a report in the current issue of the American Association of Cancer Research journal Molecular Cancer Research. Allows cells to enter circulation, increases proliferation The activity of this enzyme, which degrades the extracellular...

2009-12-25 22:10:16

Cancer progression is commonly thought of as a process involving the growth of a primary tumor followed by metastasis, in which cancer cells leave the primary tumor and spread to distant organs. A new study by researchers at Memorial Sloan-Kettering Cancer Center shows that circulating tumor cells "“ cancer cells that break away from a primary tumor and disseminate to other areas of the body "“ can also return to and grow in their tumor of origin, a newly discovered process called...

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2009-12-20 13:25:50

Up to 25% of cancer patients develop metastases in the brain "“ often long after successful treatment of the primary tumor. In almost all such cases, the prognosis is poor. The mechanisms responsible for the appearance of brain metastases have long been mysterious. Now a research team led by neurologist Dr. Frank Winkler of LMU Munich has followed, in real time, the steps that lead some tumor cells to establish metastases, while others fail to form new tumors. The team also discovered...

2009-12-02 11:24:48

UT Southwestern Medical Center researchers have found that a naturally occurring protein "” transforming growth factor beta1 (TGF-ß1) "” which normally suppresses the growth of cancer cells, causes a rebound effect after a prolonged exposure. Cancer cells go into overdrive and become even more aggressive and likely to spread, the researchers report. The mechanism for this reversal is unknown, but UT Southwestern researchers and their colleagues in...

2009-11-17 10:48:58

Findings suggest treatments should take the 'soil' away from the cancer 'seed' Targeting the normal cells that surround cancer cells within and around a tumor is a strategy that could greatly increase the effectiveness of traditional anti-cancer treatments, say researchers at The Wistar Institute. In the Journal of Clinical Investigation published online November 16, they demonstrate the critical role for fibroblast activation protein (FAP), expressed by one type of these so-called "stromal"...

2009-11-03 15:49:47

Researchers have reduced breast cancer metastasis to bone using an experimental agent to inhibit ROCK, a protein that was found to be over-expressed in metastatic breast cancer. In a study in mice, the team of researchers from Tufts University School of Medicine, the Sackler School of Graduate Biomedical Sciences at Tufts, and Tufts Medical Center report that inhibiting ROCK, or Rho-associated kinase, in the earliest stages of breast cancer decreased metastatic tumor mass in bone by 77...

2009-10-29 08:51:49

Metastases are responsible for over 90% of cancer deaths. In the upcoming issue of G&D, Dr. Robert Weinberg (MIT) and colleagues lend molecular insight into how microRNAs suppress tumor metastasis. Scott Valastyan, lead author on the study, describes it as presenting "detailed mechanistic insight regarding the process of tumor metastasis, and identifies several key regulators of this process that might prove to be interesting diagnostic and/or therapeutic targets in breast cancer." Dr....

2009-10-05 14:24:15

Researchers at The Wistar Institute have identified a key gene (KLF17) involved in the spread of breast cancer throughout the body. They also demonstrated that expression of KLF17 together with another gene (Id1) known to regulate breast cancer metastasis accurately predicts whether the disease will spread to the lymph nodes. Previously, the function of KLF17 had been unknown. Deaths of most breast-cancer patients are the result of metastasis, a complex, multi-step, and poorly understood...

2009-09-21 12:31:18

Scientists at the Burnham Institute for Medical Research in California say they've discovered reactive oxygen plays a key role in cancer metastasis. The researchers, led by Professor Sara Courtneidge, said they determined reactive species, such as superoxide and hydrogen peroxide, help form invadopodia -- cellular protrusions implicated in cancer cell migration. They found inhibiting reactive oxygen reduces invadopodia formation, thereby limiting cancer cell invasion. Reactive oxygen has a...


Word of the Day
malpais
  • The ragged surface of a lava-flow.
'Malpais' translates from Spanish as 'bad land.'