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Scientists now have a more complete understanding of how cancer cells send signals to surrounding tissues to promote development of the blood supply needed to support tumor growth. For the first time, it has been shown that signals expressed by tumor cells can directly interact with the outer membrane of adjacent blood vessel cells and influence growth and development. The research, published in the July issue of Cancer Cell, may provide a new and more efficient target for antiangiogenic...

ANN ARBOR, Mich. - University of Michigan researchers have figured out one more component in cancer cells' aggressive growth---and hope that knowledge can help kill the cells. In the July issue of Cancer Cell, the scientists explain how cancer tumor cells attach themselves to a protein on the surface of cells lining blood vessel walls. When this attachment happens, it tells the cancer cell to grow and develop blood vessels, which feed the cell. Cun-Yu Wang, senior author on the paper, said...

Scientists supported by the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health, have added a key new piece to the puzzle of how tumor cells induce new blood vessels to form and fuel their abnormal growth, a well-known process called angiogenesis. As published in this month's issue of the journal Cancer Cell, the scientists found that in addition to the well-known strategy of secreting proteins to trigger angiogenesis, tumor cells also...