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Latest Cadherin Stories

2014-05-23 11:10:34

UCSB UCSB study shows that key protein in epithelial cells plays important roles in how cells sense direction What do sled dogs and cell clusters have in common? According to research by UC Santa Barbara’s Denise Montell, they both travel in groups and need a leader to make sure they all follow in the same direction. Montell, Duggan Professor of Molecular Cellular and Developmental Biology, and colleagues worked on three independent projects involving E-cadherin, a protein found in...

2014-04-02 15:55:01

New research at Washington University School of Medicine in St. Louis and Vanderbilt University Medical Center in Nashville has implicated a poorly understood protein called PLAC8 in the spread of colon cancer. While elevated PLAC8 levels were known to be associated with colon cancer, the researchers now have shown that the protein plays an active role in shifting normal cells lining the colon into a state that encourages metastasis. The work appears April 1 in the Journal of Clinical...

2014-01-24 13:30:41

A team of scientists, led by principal investigator David D. Schlaepfer, PhD, a professor in the Department of Reproductive Medicine at the University of California, San Diego School of Medicine, has found that a protein involved in promoting tumor growth and survival is also activated in surrounding blood vessels, enabling cancer cells to spread into the bloodstream. The findings are published in this week's online issue of the Journal of Cell Biology. Blood vessels are tightly lined...

2013-06-12 16:08:32

Mechanism offers potential for interventions that could save hearing A team of NIH-supported researchers is the first to show, in mice, an unexpected two-step process that happens during the growth and regeneration of inner ear tip links. Tip links are extracellular tethers that link stereocilia, the tiny sensory projections on inner ear hair cells that convert sound into electrical signals, and play a key role in hearing. The discovery offers a possible mechanism for potential...

2013-01-07 10:59:04

Scientists know that cells in all higher organisms cells need to bind to each other for the development, architecture, maintenance and function of tissues. Mysteries have remained, however, about exactly how cells manage this feat. Scientists from the Florida campus of The Scripps Research Institute (TSRI) have now solved part of this puzzle by defining the structure of a protein known as α-catenin, which is essential to this process. The work was published online ahead of...

2012-04-25 20:17:55

Can one feel too attached? Does one need to let go to mature? Neural stem cells have this problem, too. As immature cells, neural stem cells must stick together in a protected environment called a niche in order to divide so they can make all of the cells that populate the nervous system. But when it's time to mature, or differentiate, the neural stem cells must stop dividing, detach from their neighbors and migrate to where they are needed to form the circuits necessary for humans to...

2012-03-14 21:14:04

A new study by University of Kentucky researchers provides insight into developing new treatment strategies for basal-like breast cancer, commonly known as triple-negative breast cancer. This cancer is associated with early metastasis and resistance to chemotherapy and occurs at women at a younger age. Tumor cells can exploit a cellular program that promotes cell migration and reduces adhesion between cells to spread to distant sites in the body. This cellular program, known as the...

2012-03-12 11:20:44

EDITOR'S PICK Restoring what's lost: uncovering how liver tissue regenerates The liver is unique among mammalian organs in its ability to regenerate after significant tissue damage or even partial surgical removal. Laurie DeLeve and her colleagues at the University of Southern California in Los Angeles wanted to better understand which cells are specifically responsible for driving liver regeneration. A specialized cell type, known as liver sinusoidal endothelial cells, has generally been...

2012-03-06 11:05:26

Discovered a mechanism explaining how tumor cells spread to nearby organs and structures, initiating metastasis Metastasis is responsible for 90% of deaths in patients with cancer. Understanding the mechanisms responsible for this process is one of the top goals of cancer research. The metastatic process involves a series of steps chained where the primary tumour invades surrounding tissues and ends spreading throughout the body. Ones of the first tissues undergoing metastasis are the...

2012-02-10 10:31:58

Inflammatory breast cancer (IBC) is the most lethal form of breast cancer. It spreads easily through the lymphatic and blood vessels, forming metastasis which can lead to multi-organ failure. New research published in BioMed Central's open access journal Cell Communication and Signaling demonstrates how IBC cells use IL-8, secreted as part of the anti-inflammatory response by a specific set of white blood cells (monocytes), to increase fibronectin expression. Fibronectin is a cell-adhesion...


Word of the Day
mundungus
  • A stinking tobacco.
  • Offal; waste animal product; organic matter unfit for consumption.
This word comes from the Spanish 'mondongo,' tripe, entrails.