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Latest Calcineurin Stories

Schizophrenia Linked To Abnormal Brain Network
2013-10-16 16:23:29

Alan McStravick for redOrbit.com - Your Universe Online Individuals suffering with schizophrenia are subject to a whole host of disturbing, life-changing symptoms. They can range from disorganized thinking and an inability to plan for the future to full-on hallucinations and paranoid delusions. Through treatment with psychiatric therapy and medication can be effective for some, the psychiatric disease has largely remained a medical mystery. However, researchers at the RIKEN-MIT Center...

2011-09-23 11:27:41

Immediately after transplantation, patients should minimize or avoid using certain anti-rejection drugs Patients who receive kidney transplants must take lifelong medications that, while preventing organ rejection, can also compromise other aspects of health. Immunosuppresive drugs called calcineurin inhibitors protect transplanted organs from being rejected, but they can be toxic to the kidneys over the long term and can make patients susceptible to infection, cancer, and other threats....

2010-06-23 09:24:00

LA JOLLA, Calif., June 23 /PRNewswire/ -- CalciMedica announced the appointment of Steven L. Schoenfeld, MD, as Vice President, Clinical Development. Dr. Schoenfeld's successful, clinical drug development career spans over 20 years in the pharmaceutical and biotechnology industries. He will lead CalciMedica's development efforts, assuming immediate responsibility for advancing its first CRAC Channel Inhibitor (CCI) product candidate through IND filing and into clinical development. "Steve...

2010-02-20 08:17:45

Scientists are reporting the first-ever data to show that the enzyme calcineurin is critical in controlling normal development and function of heart cells, and that loss of the protein leads to heart problems and death in genetically modified mice. Published Feb. 26 in the Journal of Biological Chemistry as the paper of the week, and posted online Feb. 19, the research was led by scientists at Cincinnati Children's Hospital Medical Center and the Howard Hughes Medical Institute. The study...

2010-02-16 08:00:00

LA JOLLA, Calif., Feb. 16 /PRNewswire/ -- CalciMedica today announced that the US Patent and Trademark Office has issued to CalciMedica US Patent No. 7,645,588, a composition patent involving STIM1, a key component of the calcium release-activated calcium (CRAC) channel. The patent, entitled "Composition comprising a cell comprising a STIM1 protein and an agent that modulates intracellular calcium and methods of use," has a priority date of March 4, 2003 and was issued on January 12, 2010....

2009-08-31 15:53:53

Canadian scientists say they've found the interaction of a specific protein regulates the development of nerve connections in the visual system of tadpoles. The researchers at the Montreal Neurological Institute and Hospital said their findings help clarify how networks of nerve cell connections become established in human brains. The scientists focused on the interactions between a schizophrenia-linked gene product, Calcineurin, and a transcription factor known to contribute to the...

2009-07-08 14:00:25

Transplant patients rely on drugs to prevent graft rejection, but at the cost of serious side effects. The class of immunosuppressive drugs known as calcineurin inhibitors (examples are cyclosporine and tacrolimus) can damage patients' kidneys and lead to high blood pressure, among other problems.A combination of treatments can effectively replace calcineurin inhibitors in preventing graft rejection when kidney transplants are performed on monkeys, scientists at the Emory Transplant Center...

2009-06-15 10:28:15

Scientists from A*STAR's Singapore Immunology Network (SIgN) and the University of Milano-Bicocca, Italy, have discovered another signaling pathway for the activation and apoptosis, or programmed cell death, of dendritic cells[1] . This discovery was published in the advanced online publication of Nature on 15 Jun 2009. Led by Prof Paola Castagnoli, Scientific Director of SIgN and Associate Prof Francesca Granucci of the University of Milano-Bicocca, the team discovered that the...

2009-06-11 07:50:04

A new drug being studied for the treatment of muscle degenerating diseases has shown promising results. According to a study published today in the British Journal of Pharmacology, Debio 025 is as effective as current drugs but, crucially, does not cause unwanted immunosuppressive effects.Bethlem Myopathy and Ullrich Congenital Muscular Dystrophy (UCMD) are muscle wasting diseases caused by deficiencies in collagen VI, a component of connective tissue. Patients are usually diagnosed at birth...

2009-05-20 14:13:20

Research in mice and human stem cells suggests new therapeutic targets Most cancers are rare in people with Down syndrome, whose overall cancer mortality is below 10 percent of that in the general population. Since they have an extra copy of chromosome 21, it's been proposed that people with Down syndrome may be getting an extra dose of one or more cancer-protective genes. The late cancer researcher Judah Folkman, MD, founder of the Vascular Biology Program at Children's Hospital Boston,...


Word of the Day
bodacious
  • Remarkable; prodigious.
  • Audacious; gutsy.
  • Completely; extremely.
  • Audaciously; boldly.
  • Impressively great in size; enormous; extraordinary.
This word is probably from the dialectal 'boldacious,' a blend of 'bold' and 'audacious.'
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