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Latest Calcium channel Stories

2012-02-01 23:36:46

Using some of the most powerful nuclear magnetic resonance equipment available, researchers at the University of California, Davis, are making discoveries about the shape and structure of biological molecules -- potentially leading to new ways to treat or prevent diseases such as breast cancer and Alzheimer's disease. The findings appear in the latest issues of the journals Nature and Journal of Biological Chemistry. "These are exquisite three-dimensional objects, and the structures...

2011-07-14 15:17:23

The human genome encodes 243 voltage-gated ion channels. Mutations in calcium channels can cause severe inherited diseases such as migraine, night blindness, autism spectrum disorders and Timothy syndrome, which leads to severe cardiovascular disorders. Katrin Depil and Anna Stary-Weinzinger together with colleagues from the Department of Pharmacology and Toxicology, University of Vienna analyzed changes in molecular organization of calcium channels caused by Timothy syndrome mutations....

2011-03-09 14:40:50

Pacemaker cells in the sinoatrial node control heart rate, but what controls the ticking of these pacemaker cells? New research by Angelo Torrente and his colleagues of the M.E. Mangoni group's, reveals, for the first time, a critical functional interaction between Cav1.3 calcium ion (Ca2+) channels and ryanodine-receptor (RyR) mediated Ca2+ signaling. The study also sheds light on a long-standing debate regarding the relative contributions of the 'funny current' generated by ion channels and...

2011-01-26 13:09:34

New finding adds significantly to our understanding of calcium channel function in health and disease Scientists in the Hotchkiss Brain Institute at the Faculty of Medicine, University of Calgary, have discovered a new mechanism that nerve cells (neurons) use to fine-tune their electrical output. The exciting discovery, published this week in the prestigious journal Nature Neuroscience, provides new insights about how the activity of the nervous system is regulated at the cellular level....

2010-02-16 08:53:56

UCSF researchers have discovered that a protein called B1N1 is necessary for the heart to contract. The findings, published in the Feb. 16 issue of the open access journal PLoS Biology, shed light not only on what makes a heart beat but also on heart failure, a disease where cardiac cells are no longer able to contract and pump blood through the body. "In all of us, a heart beat occurs about once every second. For each successful heart beat, millions of individual heart muscle cells perform...

2009-06-02 11:45:00

Screening drugs that work against defects in the tiny pores or channels that allow calcium to flow in and out cells is already easier because of a specially bred mouse that has the "pure" form of absence seizures (brief lapses in consciousness) usually seen in children, said researchers at Baylor College of Medicine in a report that appears in the current issue of the Journal of Neuroscience.Extra gene copy"This shows that an extra copy of a gene in a mouse can cause a pure form of absence...

2009-02-26 11:33:00

Expanded drug discovery and development services, cell lines, and reagents now cover nearly half of the known drugable genome CLEVELAND, Feb. 26 /PRNewswire/ -- The leading experts in ion channels and GPCR (G-protein coupled receptors) - key to drug discovery, development, and safety - are now united. ChanTest, the leading provider of ion channel testing services and validated cell lines, announced that it has acquired Rockville, Maryland-based Applied Cell Sciences. ACS is a contract...


Word of the Day
call-note
  • The call or cry of a bird or other animal to its mate or its young.
'Call-note' is newer than 'bird-call,' which originally referred to 'an instrument for imitating the note of birds' but now also refers to 'the song or cry of a bird.'
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