Quantcast

Latest Calmodulin Stories

2013-03-06 13:56:39

Some 5.8 million Americans suffer from heart failure, a currently incurable disease. But scientists at Temple University School of Medicine's (TUSM) Center for Translational Medicine have discovered a key biochemical step underlying the condition that could aid the development of new drugs to treat and possibly prevent it. "Drugs we currently use for heart failure are not very effective," explained lead investigator Walter J. Koch, PhD, Professor and Chairman of the Department of...

2012-10-22 22:25:34

A Danish-British research team has discovered a turbo switch in the vital calcium pump in our body's cells. In studies at the X-ray source DORIS at Deutsches Elektronen-Synchrotorn DESY in Hamburg and the European Synchrotron Radiation Facility ESRF in Grenoble the team discovered that the on-off switch of the pump has a previously unknown third position, which switches the pump into a turbo gear. The group of Henning Tidow from Aarhus University and Lisbeth Poulsen from the University of...

2012-02-14 11:00:00

That flutter in your heart may have more to do with the movement of sodium ions than the glance of a certain someone across a crowded room. Using the Canadian Light Source synchrotron, researchers from the University of British Columbia have revealed, for the first time, one of the molecular mechanisms that regulates the beating of heart cells by controlling the movement of sodium in out of the cells — and what calcium has to do with it. The findings, published February 14 in the...

2012-02-01 23:36:46

Using some of the most powerful nuclear magnetic resonance equipment available, researchers at the University of California, Davis, are making discoveries about the shape and structure of biological molecules -- potentially leading to new ways to treat or prevent diseases such as breast cancer and Alzheimer's disease. The findings appear in the latest issues of the journals Nature and Journal of Biological Chemistry. "These are exquisite three-dimensional objects, and the structures...

2011-03-22 16:02:53

A Cardiff University-led study has discovered that a protein provides protection against the effects of alcohol in the pancreas. The findings of the study, funded by the Medical Research Council, could lead to the development of new treatments to reduce the chances of people developing pancreatic cancer. The protein, calmodulin, is involved in the basic processes that take place in all cells, the building blocks of the body. This study reveals that when calmodulin is missing from cells in the...

2010-09-08 00:32:55

Discovery may lead to more potent drug combinations Aurora-A kinase (AurA) is an enzyme that is hyperactive in many cancers and drives tumor cell proliferation. Several AurA inhibitors are currently being tested in clinical trials to see if they slow tumor growth. Now, researchers in the Developmental Therapeutics Program at Fox Chase Cancer Center have identified an activation signal for AurA. They report in the September 7 issue of Nature Communications that a quick increase in the calcium...

2010-03-11 09:07:54

Current drugs used to treat heart failure and arrhythmias (irregular heartbeat) have limited effectiveness and have side effects. New basic science findings from a University of Iowa study suggest a way that treatments could potentially be refined so that they work better and target only key heart-related mechanisms. The team, which included researchers from Vanderbilt University, showed in theory that it might be possible to use drugs that maintain the positive effects on heart function of a...

dffa5e4c9d0c0fd428b2be49a85694c01
2010-01-26 09:39:01

EMBL scientists shed light on cellular communication systems involved in neurodegeneration, cancer and cardiovascular disease Cells rely on a range of signaling systems to communicate with each other and to control their own internal workings. Scientists from the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, have now found a way to hack into a vital communications system, raising the possibility of developing new drugs to tackle disorders like neurodegeneration, cancer and...

2009-12-05 00:44:19

Using a new mathematical model of heart cells, University of Iowa investigators have shown how activation of a critical enzyme, calmodulin kinase II (CaM kinase), disrupts the electrical activity of heart cells. The study, which also involved Columbia University, was published online Dec. 3 in the journal PLoS Computational Biology. "Recently, researchers have developed great interest in calmodulin kinase II as a critical regulator of the heart's response to injury. By targeting this enzyme's...

2005-08-08 17:37:49

CHAPEL HILL -- Scientists from the University of North Carolina at Chapel Hill School of Medicine and the UNC Lineberger Comprehensive Cancer Center have identified a protein that may inhibit cellular movement, or migration. The protein, CIB1, or calcium and integrin-binding protein 1, was originally discovered at UNC in 1997 as a blood platelet protein that may play a role in clotting. Cell migration belongs to the most rudimentary of cellular functions that allow processes such as fetal...


Word of the Day
mallemaroking
  • Nautical, the visiting and carousing of sailors in the Greenland ships.
This word is apparently from a confusion of two similar Dutch words: 'mallemerok,' a foolish woman, and 'mallemok,' a name for some persons among the crew of a whaling vessel.