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Latest Calpain Stories

2014-02-10 23:03:11

Targeting Developmental 'Road Block' Could Lead to New Treatments CHARLOTTESVILLE, VA (PRWEB) February 10, 2014 Research at the University of Virginia School of Medicine has shed light on a mysterious form of leukemia that can appear and then disappear in children with Down syndrome. The findings may have important implications for other forms of leukemia and other diseases, possibly leading to new treatments, and could one day help people with problems related to platelet...

2014-01-07 23:02:06

Two new publications by a team from Western University of Health Sciences shed further light on the mechanisms of learning and memory, and neuronal degeneration. Pomona, California (PRWEB) January 07, 2014 Two new publications by a team from Western University of Health Sciences shed further light on the mechanisms of learning and memory, and neuronal degeneration. The first paper, “A molecular brake controls the magnitude of long-term potentiation,” by Yubin Wang, Guoqi Zhu, Victor...

2013-08-08 15:06:06

Studies have shown that calpain participates in gentamicin-, neomycin- and kanamycin-induced inner ear cell apoptosis. Cisplatin has been shown to be an anticancer drug. However, cisplatin can lead to severe ototoxicity, induce cochlear cell apoptosis, and result in hearing decrease or loss, which limits the application of cisplatin in a clinical setting to a certain degree. A recent study by Liang Chang and colleagues from Jinzhou Central Hospital established a BALB/c mouse model of...

2011-10-17 20:32:10

A protein critical to development appears to have a grave impact on lungs exposed to smoking and air pollution, researchers report. Blocking that protein, called calpain, in the lungs may prove an effective way to avoid narrow, scarred blood vessels and pulmonary hypertension, said Dr. Yunchao Su, pharmacologist at Georgia Health Sciences University. "Calpain enables the bad behavior that occurs in pulmonary hypertension," said Su, corresponding author of the study published in the...

2010-01-20 13:37:06

2 major studies in 2 months make a new case for an old suspect in the mystery of how memory works A second high-profile paper in as many months has found an important role in learning and memory for calpain, a molecule whose academic fortunes have ebbed and flowed for 25 years. USC's Michel Baudry (then at the University of California, Irvine) and Gary Lynch (UC Irvine) first pointed to calpain as the key to memory in a seminal 1984 paper in Science on the biochemistry of memory. In a paper...

2009-12-08 19:59:47

Risky therapy for aging brain may be avoidable by focusing instead on hormone's target, USC neuroscientists suggest Estrogen seems to act like a middleman in its positive effect on the brain, raising the possibility that future drugs may bypass the carcinogenic hormone altogether while reaping its benefits. A split-personality chemical, estrogen is thought to protect neural circuits and boost learning and memory, while at the same time increasing cancer risk when taken in high doses. In a...

2009-09-07 06:43:08

UCSF researchers have successfully used protease inhibitors to restore to normal levels a key protein involved in early brain development. Reduced levels of that protein have been shown to cause the rare brain disorder lissencephaly, which is characterized by brain malformations, seizures, severe mental retardation and very early death in human infants. The findings offer a proof-of-principle, at least in mice, that the genetic equivalent to human lissencephaly, also known as "smooth brain"...

2009-04-05 07:27:50

Researchers at the University of Pennsylvania have discovered that parasites hijack host-cell proteins to ensure their survival and proliferation, suggesting new ways to control the diseases they cause. The study, appearing this week online in Science, was led by Doron Greenbaum, PhD, Assistant Professor of Pharmacology in the Penn School of Medicine."Researchers can now develop ways to kill parasites by placing roadblocks in the path they use to destroy their victims," says Greenbaum. The...

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2009-01-29 13:49:59

Researchers seeking ways to defeat malaria have found a way to get help from the parasite that causes the disease. Scientists at Washington University School of Medicine in St. Louis stepped aside and let Plasmodium falciparum, one of the deadliest strains of malaria, do a significant portion of the genetic engineering work in their new study. With that help, they could unambiguously show that the parasite relies heavily on a one-of-a-kind protein that it only makes in small quantities, two...

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2008-04-30 08:56:26

New study in the FASEB Journal identifies c-FLIP and calpain-3 proteins as drug targets in limb-girdle muscular dystrophy and other conditionsA team of French and German researchers report in the May 2008 print issue of The FASEB Journal that people with limb-girdle muscular dystrophy are missing a protein called c-FLIP, which the body uses to prevent the loss of muscle tissue. By targeting the cellular and molecular mechanisms responsible for creating this protein, scientists could develop...


Word of the Day
omadhaun
  • A fool; a simpleton: a term of abuse common in Ireland and to a less extent in the Gaelic-speaking parts of Scotland.
This word is partly Irish in origin.