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Latest Caretaker gene Stories

2011-06-09 23:29:26

Mutations in genes essential to survival are behind so-called orphan diseases, explaining in part why these diseases are rare and often deadly, according to a study appearing in The American Journal of Human Genetics. The new finding contrasts sharply with what is known about mutations in non-essential genes being the drivers of common diseases having higher prevalence rates, according to scientists at Cincinnati Children's Hospital Medical Center who conducted the research. The...

2011-05-18 14:32:00

New research from North Carolina State University shows that a "gatekeeper" protein plays an important role in skin-cancer prevention in humans and lab mice. The protein, C/EBP alpha, is normally abundantly expressed to help protect skin cells from DNA damage when humans are exposed to sunlight. The NC State research shows, however, that the protein is not expressed when certain human skin cancers are present. Moreover, when the protein is inactivated in special lab mice exposed to small...

2011-02-02 19:44:41

A factor in multiple myeloma, and other conditions For several decades, researchers have been linking genetic mutations to diseases ranging from cancer to developmental abnormalities. What hasn't been clear, however, is how the body's genome sustains such destructive glitches in the first place. Now a team of Mayo Clinic scientists and collaborators provide an unprecedented glimpse of a little-understood gene, called MMSET, revealing how it enables disease-causing mutations to occur. The...

2011-01-18 22:25:41

Scientists at The University of Nottingham have brought cancer cells back under normal control "” by reactivating their cancer suppressor genes. The discovery could form a powerful new technology platform for the treatment of cancer of the breast and other cancers. Breast cancer is diagnosed in about 1.4 million women throughout the world every year, with half a million dying from the disease. A common cause of cancer is when cells are altered or mutated and the body's tumour suppressor...

2010-12-14 14:36:37

There are many mechanisms that alter the activity of genes "“ direct changes to the DNA code like mutations and deletions, or changes that control when genes are switched on and off, called epigenetic means. Tumor-suppressor genes are often inactivated through epigenetics, which provides an opening for the cancerous growth of cells. Researchers at the Duke Cancer Institute have found evidence of epigenetics at work on a genome-wide scale in cases of ovarian cancer. One major biological...

2010-11-10 00:57:42

A gene thought to be responsible for initiating human cancer has been identified by researchers at Barts and The London School of Medicine and Dentistry. The study - published online today (9 November) in the journal Cancer Research - paves the way for developing early cancer diagnostic tests, and finding new treatments that prevent or stop the spread of cancer cells at an early stage. Led by Dr Muy-Tek Teh of the Institute of Dentistry at Barts and The London School of Medicine and...

2010-11-02 08:09:11

(Ivanhoe Newswire) -- With 655,000 deaths worldwide per year from colorectal cancer, it is the fourth most common form of cancer in the United States.  Although it generally occurs in patients 60 and up, younger patients have been known to develop the cancer with no family history of it, and until now, researchers have been bemused as to why this occurs.  A recent study has uncovered a link involving telomeres and an increased risk for colorectal cancer in younger age groups that...

2010-09-22 13:19:17

If you are more inclined to love thyself than thy neighbor, it could be your mother's fault If you are more inclined to love thyself than thy neighbor, it could be your mother's fault. Those are the findings of Francisco Úbeda, assistant professor of ecology and evolutionary biology at the University of Tennessee, Knoxville. Úbeda, along with fellow evolutionary biologist Andy Gardner from Oxford University, examined the impact that...

2010-09-10 12:02:43

Scientists at the Johns Hopkins Kimmel Cancer Center have identified two genes whose mutations appear to be linked to ovarian clear cell carcinoma, one of the most aggressive forms of ovarian cancer. Clear cell carcinoma is generally resistant to standard therapy. In an article published online in the September 8 issue of Science Express, the researchers report that they found an average of 20 mutated genes per each ovarian clear cell cancer studied. Two of the genes were more commonly...

2010-08-16 16:33:32

Researchers at the University of Gothenburg, Sweden, have for the first time identified 12 genes that could be associated with aggressive breast tumors. The discovery could result in more reliable prognoses and better treatment strategies for patients. The results, published in the journal Clinical Cancer Research, are based on analyses of breast tumors from 97 female breast cancer patients. Half of these patients died within eight years of diagnosis, while the remainder survived for more...


Word of the Day
barratry
  • The offense of persistently instigating lawsuits, typically groundless ones.
  • An unlawful breach of duty on the part of a ship's master or crew resulting in injury to the ship's owner.
  • Sale or purchase of positions in church or state.
This word ultimately comes from the Old French word 'barater,' to cheat.
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