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Latest Caretaker gene Stories

2010-08-13 10:33:00

MANHATTAN, Kan., Aug. 13 /PRNewswire-USNewswire/ -- A microscopic gene may play a gigantic role when it comes to cancerous tissue in the human body, according to one Kansas State University research team. The team is investigating mutation within the ADAM12 gene of the A Disintegrin and Metalloprotease family, or ADAM family, and its role in breast cancer. "We want to know whether ADAM12 is a good guy or a bad guy in breast cancer," said Anna Zolkiewska, associate professor of...

2010-03-30 13:52:42

COLUMBUS, Ohio "“ An important gene that normally protects the body against cancer can itself cause a variety of cancers depending on the specific mutation that damages it, according to a new study by investigators at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James). The study examined mutations in a gene called PTEN. People who inherit a mutated copy of this gene have Cowden syndrome, a...

2010-02-17 12:54:56

Screening cancer genomes for the driver mutations in tumor suppressor genes A new study of mutations in cancer genomes shows how researchers can begin to distinguish the 'driver' mutations that push cells towards cancer from the 'passenger' mutations that are a by-product of cancer cell development. The study also shows that at least one in nine genes can be removed without killing human cells. Many cancer genomes are riddled with mutations. The vast majority of these are likely to be...

2010-01-14 13:47:50

According to modern biology textbooks, a single genetic mutation is rarely enough to cause cancer. It is generally thought that cells must accumulate a series of mutations that work together to trigger tumor development. Now, Howard Hughes Medical Institute (HHMI) researchers have shown that distinct cancer-causing mutations in neighboring cells can cooperate to produce tumors. Cancer biologists have long known that it takes the cooperation of multiple cancer-causing genes - or oncogenes --...

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2010-01-07 08:20:10

Mutations in the genome regulation machinery identified in clear cell renal cell carcinoma In a new study, scientists have searched for mutations in the gene regions of more than 100 kidney cancer samples, the largest number of samples from a single tumor type to be sequenced to date. Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer, with 102,000 deaths worldwide each year. It is noteworthy because its pathology "“ all the visible clues to its nature...

2010-01-05 14:46:00

Scientists at The University of Nottingham have found that a group of genetic rogue elements, produced by DNA sequences commonly known as "Ëœjunk DNA', could help diagnose breast and bowel cancer. Their research, funded by Cancer Research UK, is published in this month's Genomics journal. The researchers, led by Dr Cristina Tufarelli, in the School of Graduate Entry Medicine and Health Sciences, discovered that seven of these faulty genetic elements "” known as chimeric...

2009-12-17 12:52:32

Professor Dr. Sanford Markowitz details promising findings leading to reducing the burden of the disease Every year in the United States, 160,000 cases of colorectal cancer are diagnosed, and 57,000 patients die of the disease, making it the second leading cause of death from cancer among adults, after lung cancer. As researchers and clinicians fervently look for causes and cures for colorectal cancer -- simultaneously generating thousands of studies producing more and more promising results...

2009-12-15 12:56:41

Tumor suppressor genes make proteins that help control cell growth. Mutations in these genes that generate nonfunctional proteins can contribute to tumor development and progression. One of the most well-known tumor suppressor genes is BRACA1, mutations in which are linked to breast cancer. Ze-Guang Han and colleagues, at the Chinese National Human Genome Center at Shanghai, People's Republic of China, have now identified SCARA5 as a candidate tumor suppressor gene in human hepatocellular...

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2009-12-10 08:40:00

By looking at yeast cells, Jeffrey Laney, assistant professor of biology, has figured out one way in which cells can transform themselves: a cellular "machine" removes a regulatory "lid." Details are published online in Nature Cell Biology. Cells are not static. They can transform themselves over time "” but change can have dangerous implications. Benign cells, for example, can suddenly change into cancerous ones. That's one reason why scientists are trying to figure out why and how...

2009-11-13 09:54:15

One difficulty with fighting cancer cells is that they are similar in many respects to the body's stem cells. By focusing on the differences, researchers at Karolinska Institutet have found a new way of tackling colon cancer. The study is presented in the prestigious journal Cell. Molecular signal pathways that stimulate the division of stem cells are generally the same as those active in tumor growth. This limits the possibility of treating cancer as the drugs that kill cancer cells also...


Word of the Day
ramage
  • Boughs or branches.
  • Warbling of birds in trees.
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