Latest Caretaker gene Stories
Biologists at New York University have discovered a system by which a random choice between two distinct cellular fates in the fruit fly eye becomes firmly established. Surprisingly, the genes involved are known 'tumor suppressor genes', i.e. genes that are inactivated in some forms of cancer due to uncontrolled cell proliferation. Because the fly eye is highly amenable to genetic analysis, these findings, published in the latest issue of Cell, could help decipher the mechanisms by which...
Surprising findings from just five patients has led to the first proof of how the rare disorder Fanconi anemia causes chromosomal instability. A team of international researchers, led by scientists at Rockefeller University, reports the findings in the September issue of Nature Genetics.
Prostate cancer, the second leading cause of cancer death for men in the United States, is caused by changes in several tummor suppressor genes including PTEN and p53. Up to 70 percent of men with prostate cancer have lost one copy of the PTEN gene at the time of diagnosis, and p53 is absent in a high number of patients with advanced prostate cancer.
Researchers focused on the causes and treatment of lung cancer have located nearly 100 chromosome areas where potentially related genes are either missing or are over-copied.