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Latest Caspase Stories

2009-10-16 10:35:48

A series of studies have demonstrated that Chrysanthemum indicum possesses antimicrobial, antiinflammatory, immunomodulatory, and neuroprotective effects. Recently, much attention has been devoted to the anticancer activity of Chrysanthemum indicum, especially in hepatocellular carcinoma (HCC). However, its anticancer mechanism of action is still not clear and needs further investigation. A research article to be published on September 28, 2009 in the World Journal of Gastroenterology...

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2009-10-13 10:27:09

International research teams has shown that parts of the genetic programs that determine programmed cell death in plants and animals are actually evolutionarily related and moreover function in a similar way Research has previously assumed that animals and plants developed different genetic programs for cell death. Now an international constellation of research teams, including one at the Swedish University of Agricultural Sciences, has shown that parts of the genetic programs that determine...

2009-09-21 13:47:42

Caspase-3 Cleaves in Unforeseen Ways Investigators at Burnham Institute for Medical Research (Burnham) have identified novel cleavage sites for the enzyme caspase-3 (an enzyme that proteolytically cleaves target proteins). Using an advanced proteomic technique called N-terminomics, Guy Salvesen, Ph.D., professor and director of the Apoptosis and Cell Death Research program of Burnham's NCI-designated Cancer Center, and colleagues determined the cleavage sites on target proteins and found,...

2009-09-10 07:00:00

MALVERN, Pa., Sept. 10 /PRNewswire/ -- Ascenta Therapeutics announced today that following the approval by the U.S. Food and Drug Administration (FDA) of its Investigational New Drug (IND) Application for AT-406, an orally-active, small molecule, multi-IAP antagonist, the company will initiate a Phase I clinical trial in patients with advanced cancer during the fourth quarter of 2009. (Logo: http://www.newscom.com/cgi-bin/prnh/20090227/PH75873LOGO ) "We are very pleased to be moving our...

2009-07-24 11:35:00

Scientists at Burnham Institute for Medical Research (Burnham) have found that the Caspase-8 protein, long known to play a major role in promoting programmed cell death (apoptosis), helps relay signals that can cause cancer cells to proliferate, migrate and invade surrounding tissues. The study was published in the journal Cancer Research on June 15.The team of scientists, led by Kristiina Vuori, M.D., Ph.D., professor and director of the Cancer Center at Burnham, showed that Caspase-8 caused...

2009-07-22 14:30:00

The role of a protein called XIAP in the regulation of cell death has been identified by Walter and Eliza Hall Institute researchers and has led them to recommend caution when drugs called IAP inhibitors are used to treat cancer patients with underlying liver conditions.A team led by Professor Andreas Strasser from the institute's Molecular Genetics of Cancer division has found that XIAP (X-chromosome-linked inhibitor of apoptosis protein) is the critical factor that determines which of two...

2009-07-13 13:34:37

 Going out like a brilliant flame is one way to get attention. If physicians could watch tumor cells committing a form of programmed suicide called apoptosis, a desired effect of workhorse cancer treatments such as chemotherapy and radiotherapy, they could more quickly pick the most effective treatment. Now scientists at the Stanford University School of Medicine have found a way to do just that, by lighting up cells as they die.Apoptosis is a carefully orchestrated sequence of...

2009-06-29 09:47:25

A research article to be published on June 21, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Yan Li from Shengjing Hospital of China Medical University studied the growth inhibitory effects of Alisol B acetat and determined its mechanism of antitumor activity in human gastric cancer cell line SGC7901.Professor Li and his colleagues found that Alisol B acetat could inhibit the proliferation of SGC7901 cell in a time and dose dependent...

2009-05-12 23:38:06

Women have a more powerful immune system than men, researchers in Montreal found. The study, published in the Proceedings of the National Academy of Sciences, found the production of estrogen by females could have a beneficial effect on the innate inflammatory response against bacterial pathogens. Dr. Maya Saleh of the McGill University Health Centre and McGill University said estrogen naturally produced in women seems to block the production of the enzyme Caspase-12, which blocks the...

2009-05-12 12:00:00

MUHC researchers demonstrate that estrogen renders the innate immune system of women more powerful than that of men When it comes to immunity, men may not have been dealt an equal hand. The latest study by Dr. Maya Saleh, of the Research Institute of the McGill University Health Centre and McGill University, shows that women have a more powerful immune system than men. In fact, the production of estrogen by females could have a beneficial effect on the innate inflammatory response...


Word of the Day
ramage
  • Boughs or branches.
  • Warbling of birds in trees.
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