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Latest Caspase Stories

2009-04-21 09:00:00

- Data on novel pro-apoptotic agent presented at the 100th Annual Meeting of the American Association for Cancer Research - - University of Pennsylvania data on chemotherapy resistance patterns in neuroblastoma cell lines, highlighting AT-101's inhibition of Mcl-1, also presented - MALVERN, Pa., April 21 /PRNewswire/ -- Ascenta Therapeutics announced today that the results of preclinical studies of its orally-active, small molecule, pro-apoptotic agent, AT-406, have been presented at the...

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2009-03-25 09:37:01

Diabetes and eczema may appear to be two completely unrelated diseases. But UC San Diego biologists have uncovered what appears to be a crucial biochemical link between the two. The scientists report in the March 26 issue of the journal Nature their discovery that a protein previously linked only to cell death, plays a critical role in the healing of wounds in laboratory mice. This protein, known as caspase 8, is deficient in humans with eczema, but produced in excess amounts by diabetics....

2009-02-19 15:17:58

U.S. researchers have discovered a new route through which Alzheimer's disease may either trigger or maintain the destruction of brain cells. A team of scientists at the biotechnology firm Genentech Inc., discovered that beta-amyloid precursor protein, known as APP, and death receptor 6 trigger a widespread self destruction program that relies on caspases -- sometimes called executioner proteins because of the role they play in apoptosis, or programmed cell death, Medical News Today...

2009-01-01 08:24:58

Medicinal plants have been used as traditional remedies for hundreds of years. Among them, S. barbata has been traditionally used in treatment of hepatitis, inflammation, osteomyelitis and gynecological diseases in China. Studies indicate that extracts from S. barbata have growth inhibitory effects on a number of human cancers. Reports are available on the treatment of lung, breast and digestive system cancer, hepatoma, and chorioepithelioma with S. barbata extracts. However, the underlying...

2008-10-30 21:00:11

Pre-clinical studies presented at the 9th International Conference on Membrane Redox Systems in Wellington New Zealand this week demonstrate that Novogen's NV-128 (a novel mTOR inhibitor), when used in combination with the Marshall Edwards, Inc.'s Phase III anti-ovarian cancer drug, phenoxodiol, produces potent synergistic anti-cancer activity against non-small cell lung carcinoma cell lines (NSCLC). Importantly, the synergistic cytotoxicity observed between NV-128 and phenoxodiol was...

2008-10-05 03:00:08

By Bacqueville, Daniel Mavon, Alain ABSTRACT In the present study, a convenient and easy-to-handle skin organ culture was developed from domestic pig ears using polycarbonate Transwell(R) culture inserts in 12-well plate. This alternative model was then tested for its suitability in analyzing the shortterm effects of a single solar radiation dose (from 55 to 275 kJ m^sup -2^). Differentiation of the pig skin was maintained for up to 48 h in culture, and its morphology was similar to that of...

2008-09-05 06:00:23

Neurologix, a biotechnology company engaged in the development of gene therapies for the brain and central nervous system, and Aegera Therapeutics, a private clinical stage company focused on oncology and neuropathic pain, have executed an exclusive license agreement. Pursuant to the agreement, Neurologix has exclusively licensed the worldwide rights, excluding China, for the use of the x-linked inhibitor of apoptosis protein (XIAP) gene for therapeutic or prophylactic purposes in the...

2008-08-13 18:00:14

By Vaux, David Proteins that cause cell death in insects are showing promise as anti-cancer drugs. Every second, about a million of our cells complete the process of cell division to generate an extra million cells. To maintain the correct cell number, and so we don't get bigger and bigger, it is necessary that an equal number of cells are removed. Cells are disposed of by an intracellular self-destruct process termed "apoptosis". Since you started reading this article, 100 million cells...

2008-08-07 09:01:06

BOTHELL, Wash., Aug. 7, 2008 (PRIME NEWSWIRE) -- Sonus Pharmaceuticals, Inc. (Nasdaq:SNUS) announced today that it has signed an exclusive in-licensing agreement with Bayer HealthCare LLC for development of a family of compounds known as caspase activators presently in preclinical research. Caspase activators consist of small molecules that have been identified in preclinical research as activators of programmed cell death. Unlike normal cells, many tumor cell types have lost the ability to...

2008-07-17 12:01:18

GNI and EpiCept have reached an agreement to develop a new therapeutic drug, EP1013, in Asia, Australia, and New Zealand, for late-stage viral infection-induced hepatitis. Under the agreement, EpiCept will retain the rights in the rest of the world. GNI's wholly owned subsidiary, Shanghai Genomics, will start preparation for pre-investigational new drug (IND) application and clinical development in China immediately. In return for granting a license to GNI to develop EP1013, EpiCept...


Word of the Day
siliqua
  • A Roman unit of weight, 1⁄1728 of a pound.
  • A weight of four grains used in weighing gold and precious stones; a carat.
  • In anatomy, a formation suggesting a husk or pod.
  • The lowest unit in the Roman coinage, the twenty-fourth part of a solidus.
  • A coin of base silver of the Gothic and Lombard kings of Italy.
'Siliqua' comes from a Latin word meaning 'a pod.'
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