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Latest Caspase Stories

2008-06-25 09:02:27

By Blankenberg, Francis G After several decades of debate, it is now widely acknowledged that apoptosis, also known as programmed cell death, is central to homoeostasis and normal development and physiology in all multicellular organisms, including humans. The dysregulation of apoptosis can lead to the destruction of normal tissues in a variety of disorders, including autoimmune and neurodegenerative diseases (too much apoptosis) or the growth of tumors (too little apoptosis). In addition,...

2008-06-16 12:01:04

Critical Outcome Technologies has received confirmatory experimental results that have identified a novel and potentially first in class mechanism of action for its lead cancer drug candidate, COTI-2. Experiments conducted in triplicate have confirmed that COTI-2 has a profound effect on caspase-9 activation through inhibition of Akt/PKB. According to the company, the resulting activation of caspase-9 leads to a vigorous apoptosis or programmed cell death in cancer cells. Wayne Danter,...

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2008-03-27 13:45:00

Researchers have identified a key player in the killing of brain cells after a stroke or a seizure. The protein asparagine endopeptidase (AEP) unleashes enzymes that break down brain cells' DNA, scientists at Emory University School of Medicine have found.The results are published in the March 28 issue of the journal Molecular Cell.Finding drugs that block AEP may help doctors limit permanent brain damage following strokes or seizures, says senior author Keqiang Ye, PhD, associate professor...

2005-10-06 17:15:00

DURHAM, N.C. -- An immature egg's internal nutrient supply is critical to its survival, an insight that offers a new route to understanding and treating infertility due to egg death, according to Duke University Medical Center researchers. As women age, their stockpile of immature eggs, called oocytes, diminishes through cell death, eventually leading to infertility. In studies with frog oocytes, the Duke researchers found that the nutrient storehouse, or yolk, plays a key role in...

2005-09-20 16:01:06

The loss of function of a gene called FOXO1a plays an important role in the development of the most common cancer of soft tissues in children, and restoring the function of that gene in cancer cells suppresses that cancer, according to investigators at St. Jude Children's Research Hospital. The cancer, called alveolar rhabdomyosarcoma (ARMS), arises from immature skeletal muscle cells that remain partially differentiated (do not acquire all the characteristics of a mature muscle cell). The...


Word of the Day
grass-comber
  • A landsman who is making his first voyage at sea; a novice who enters naval service from rural life.
According to the OED, a grass-comber is also 'a sailor's term for one who has been a farm-labourer.'