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Latest Cd4+ T cells and antitumor Immunity Stories

2014-03-25 08:30:19

Modified MIC Proteins as Targeted Immunotherapy for Cancer and Virus-Infected Cells SOUTH SAN FRANCISCO, Calif., March 25, 2014 /PRNewswire/ -- AvidBiotics Corp., a privately held biotechnology company developing novel, non-antibody proteins targeting cancer and virus-infected cells, today announced that it has received an issued patent from the U.S. Patent and Trademark Office covering the targetable immunotherapeutic platform being developed by the company. US Patent No....

2012-12-19 11:28:22

Researchers at the University of California, San Diego School of Medicine report that tumor cells use stress signals to subvert responding immune cells, exploiting them to actually boost conditions beneficial to cancer growth. The findings are published in the December 18 online issue of the journal PLOS ONE. Lead author Navin R. Mahadevan, a graduate student in the Laboratory of Immunology at the UC San Diego Moores Cancer Center, and colleagues found that tumor cells manipulate a...

2012-12-11 15:17:13

Researchers at the Moffitt Cancer Center have found that delayed tumor growth and enhanced survival of mice bearing melanoma were possible by blocking the reconstitution of myeloid-derived suppressor cells and Tregs (suppressors of anti-tumor activity) after total body irradiation had eliminated them. Blocking myeloid-derived suppressor cells and regulatory T-cell reconstitution improved adoptive T-cell therapy, an immunotherapy designed to suppress tumor activity. The study appears in the...

2012-10-03 14:41:16

How tumors exploit microflora and immune cells to fuel growth Researchers at the University of California, San Diego School of Medicine report the discovery of microbial—dependent mechanisms through which some cancers mount an inflammatory response that fuels their development and growth. The findings are published in the October 3, 2012 Advanced Online Edition of Nature. The association between chronic inflammation and tumor development has long been known from the early work...

2012-06-11 20:07:02

The human immune system has a natural ability to identify and attack tumor cells. Natural killer (NK) cells are innate immune cells that are particularly effective at killing tumor cells due to their ability to secrete cytotoxic enzymes. However, mutations have allowed many types of tumors to develop a resistance to NK-mediated killing through ill-defined mechanisms. Dr. Jerome Ritz and colleagues at the Dana-Farber Cancer Institute in Boston sought to pinpoint some of these mechanisms using...

2012-04-02 20:35:45

Scientists may have discovered a new paradigm for immunotherapy against cancer by priming antibodies and T cells with cancer stem cells, according to a study published in Cancer Research, a journal of the American Association for Cancer Research. "This is a major breakthrough in immunotherapy research because we were able to use purified cancer stem cells to generate a vaccine, which strengthened the potency of antibodies and T cells that selectively targeted cancer stem cells," said Qiao...

2012-03-19 10:12:38

The utility of a naturally occurring protein given, sometimes to great effect, as a drug to treat advanced cancers is limited by the severe side effects it sometimes causes. But a Stanford University School of Medicine scientist has generated a mutant version of the protein whose modified shape renders it substantially more potent than the natural protein while reducing its toxicity. The protein, known as interleukin-2 or IL-2, is a master regulator of the immune system. It acts as a...

2012-03-06 12:07:57

Researchers from the Perelman School of Medicine at the University of Pennsylvania report this month in Cancer Research a universal approach to personalized cancer therapy based on T cells. It is the first time a system for making an adaptable, engineered T-cell to attack specific tumor types has been proposed, depending on which abnormal proteins, called antigens, are expressed by individual patients´ tumor cells. For now, the system is being refined in experiments using healthy...


Word of the Day
omadhaun
  • A fool; a simpleton: a term of abuse common in Ireland and to a less extent in the Gaelic-speaking parts of Scotland.
This word is partly Irish in origin.