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Latest Cd4+ T cells and antitumor Immunity Stories

2012-02-27 07:24:19

Study in Nature Medicine could lead to novel therapy for cancer In a study published in Nature Medicine, Loyola researchers report on a promising new technique that potentially could turn immune system killer T cells into more effective weapons against infections and possibly cancer. The technique involves delivering DNA into the immune system's instructor cells. The DNA directs these cells to overproduce a specific protein that jumpstarts important killer T cells. These killer cells...

2012-02-09 10:45:10

DNA sequences from tumor cells can be used to direct the immune system to attack cancer, according to scientists at Washington University School of Medicine in St. Louis. The research, in mice, appears online Feb. 8 in Nature. The immune system relies on an intricate network of alarm bells, targets and safety brakes to determine when and what to attack. The new results suggest that scientists may now be able to combine DNA sequencing data with their knowledge of the triggers and targets...

2012-01-19 13:40:27

In a study investigating immune response in cancer, researchers from Moffitt Cancer Center in Tampa, Fla., and the University of South Florida have found that interaction between the immune system's antigen-specific CD4 T cells and myeloid-derived suppressor cells (MDSC) - cells that play a major role in cancer-related immune suppression - dramatically change the nature of MDSC-mediated suppression. By contrast, the same effect was not observed when MDSCs interacted with the immune system's...

2011-11-08 21:17:52

At first it sounds like good news: The body's own immune system gets active in almost every cancer — however, not necessarily for the benefit of the patient. "We distinguish between two different types of immune response," says Professor Dr. Viktor Umansky, immunologist at DKFZ and University Medical Center Mannheim. "On the one hand, cells of the immune system specifically attack tumor cells. On the other, however, almost every tumor causes in its microenvironment a chronic...

2011-09-08 09:43:27

Like humans, mice that live in their natural habitat encounter bacteria and other pathogens that exercise their immune system, yet the lab mice typically used in immunology studies are raised in isolation from most diseases. A study on natural killer cells in wild mice published this week in Molecular Ecology examines the hypothesis that the unsterile living conditions faced by humans and wild mice may improve the readiness of the immune system to fight new infections. The findings suggest...

2011-06-14 13:36:14

A team of Melbourne scientists has discovered a new type of cell in the immune system. The new cell type, a kind of white blood cell, belongs to a family of T-cells that play a critical role in protection against infectious disease. Their findings could ultimately lead to the development of novel drugs that strengthen the immune response against particular types of infectious organisms. It is also potentially significant for many other important diseases including allergies, cancer and...

2011-06-07 06:26:50

(Ivanhoe Newswire) --Cancer typically doesn't kill someone as a result of the initial tumor but as a result of tumors at distant sites that are derived from the initial tumor. Pregnancy appears to be permissive for tumor metastasis. Breast tumors that arise during pregnancy tend to spread earlier to distant sites. This study has uncovered a possible reason for this. Ivan Stamenkovic, at the University of Lausanne, Switzerland and colleagues found that the increased metastasis from tumors of...

2011-04-12 14:30:45

A molecule that lies dormant until it encounters a cancer cell, then suddenly activates and rouses the body's immune system to fight cancer cells directly, marks the latest step in scientists' efforts to tap the body's own resources to fight the disease. The developers of the technology at the University of Rochester Medical Center dub it the "Pacman strategy" because it hinges upon molecular machines produced in abundance by tumors to chew through and gobble up particular chains of...

2010-11-04 18:07:35

New research could lead to improved vaccines for cancerous tumors Researchers at the University of Cambridge hope to revolutionise cancer therapy after discovering one of the reasons why many previous attempts to harness the immune system to treat cancerous tumours have failed. New research, published today in the journal Science, reveals that a type of stromal cell found in many cancers which expresses fibroblast activation protein alpha (FAP), plays a major role in suppressing the immune...


Word of the Day
mundungus
  • A stinking tobacco.
  • Offal; waste animal product; organic matter unfit for consumption.
This word comes from the Spanish 'mondongo,' tripe, entrails.