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Latest CD4 Stories

2012-04-18 19:59:54

In wealthy countries, antiretroviral therapy (ART) has transformed AIDS into an often-manageable chronic condition, as patients can receive both the therapeutics and the constant monitoring that ensures the therapies remain effective. Developing nations, however, frequently need to balance expansion of treatment access versus the economic resources to sustain the routine blood testing that ART requires. At a time when global funding commitments for AIDS therapy programs are being cut, there...

2012-03-27 01:01:41

The hallmark loss of helper CD4+ T cells during human immunodeficiency virus (HIV) infection may be a red herring for therapeutics, according to a study published on March 26th in the Journal of Experimental Medicine. HIV preferentially infects CD4+ T cells, immune cells required to generate protective antibodies. In many people, this leads to a progressive drop in CD4+ T cell numbers–and the more the numbers fall, the faster AIDS develops. HIV-induced cell loss includes both 'naive'...

2012-03-21 10:24:37

Using data from the Collaboration of Observational HIV Epidemiological Research in Europe (COHERE), Jim Young and colleagues from The Opportunistic Infections Project Team of COHERE show in this week's PLoS Medicine that in successfully treated patients, the risk of a new AIDS event or death follows a CD4 cell count gradient in patients with viral suppression. An increase in CD4 cell count provides the greatest benefit for patients with a CD4 cell count below 200 cells/µL but still...

2012-01-19 13:40:27

In a study investigating immune response in cancer, researchers from Moffitt Cancer Center in Tampa, Fla., and the University of South Florida have found that interaction between the immune system's antigen-specific CD4 T cells and myeloid-derived suppressor cells (MDSC) - cells that play a major role in cancer-related immune suppression - dramatically change the nature of MDSC-mediated suppression. By contrast, the same effect was not observed when MDSCs interacted with the immune system's...

2011-12-01 18:47:55

Results of clinical trial in Uganda suggest better way to spend money fighting disease in rural Africa A cheaper laboratory test that helps guide anti-retroviral drug treatment for people with HIV/AIDS may be just as effective as a more sophisticated test, a group of international researchers has found — a discovery that could be particularly important in rural Africa. While the findings by researchers in the United States, Canada and Uganda must still be confirmed through...

2011-10-27 22:10:50

Caltech biologists create neutralizing antibody that shows increased potency Using highly potent antibodies isolated from HIV-positive people, researchers have recently begun to identify ways to broadly neutralize the many possible subtypes of HIV. Now, a team led by biologists at the California Institute of Technology (Caltech) has built upon one of these naturally occurring antibodies to create a stronger version they believe is a better candidate for clinical applications. Current...


Word of the Day
attercop
  • A spider.
  • Figuratively, a peevish, testy, ill-natured person.
'Attercop' comes from the Old English 'atorcoppe,' where 'atter' means 'poison, venom' and‎ 'cop' means 'spider.' 'Coppa' is a derivative of 'cop,' top, summit, round head, or 'copp,' cup, vessel, which refers to 'the supposed venomous properties of spiders,' says the OED. 'Copp' is still found in the word 'cobweb.'
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