Latest CDH1 Stories

Inflammatory breast cancer (IBC) is a very rare and aggressive disease that progresses rapidly and is associated with a very low survival rate. To understand how this type of cancer spreads, it's crucial to characterize the interactions between cancer cells and their 3D environment. Researchers at Fox Chase Cancer Center have developed a novel, 3D culture system that mimics the environment surrounding these cancer cells. This model could be used to test new anticancer drugs capable of...

Researchers at Mayo Clinic in Florida have found that a molecule long believed to be a beneficial tumor suppressor "” and thus a potential cancer drug target "” appears to act as an oncogene in some lethal brain tumors.The protein, epithelial cadherin (E-cadherin), is known for its ability to keep cancer cells glued together, preventing them from breaking away and metastasizing. But, based on their findings, published online in PLoS ONE, the scientists suggest E-cadherin can also function...

New research in the Journal of Cell Biology helps explain how the toxic protein responsible for botulism can enter circulation from the digestive system. The study appears online May 10.Botulism, a rare but serious paralytic illness, is caused by botulinum neurotoxin (BoNT), an extremely toxic protein that is produced by the bacterium Clostridium botulinum. In food-borne botulism, the nontoxic components of BoNT"”including hemagglutinin (HA)"”protect the toxin from the low pH and enzymes...