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Latest Cell signaling Stories

2012-06-19 00:03:38

International collaboration puts molecular face on enzyme family that allows plants to adjust quickly to herbivore attack or changes in growing conditions Science has known about plant hormones since Charles Darwin experimented with plant shoots and showed that the shoots bend toward the light as long as their tips, which are secreting a growth hormone, aren´t cut off. But it is only recently that scientists have begun to put a molecular face on the biochemical systems that...

2012-06-12 06:23:43

In a pair of related studies, scientists from the Florida campus of The Scripps Research Institute have identified several proteins that help regulate cells´ response to light–and the development of night blindness, a rare disease that abolishes the ability to see in dim light. In the new studies, published recently in the journals Proceedings of the National Academy of Sciences (PNAS) and The Journal of Cell Biology, Scripps Florida scientists were able to show that a family of...

2012-05-16 22:24:14

Scientists optimistic that targeting pathway's cellular transcription process will lead to death of multiple myeloma cells Researchers at NYU School of Medicine have identified a target for slowing the progression of multiple myeloma by using currently available drugs. Published recently in Nature Cell Biology, the study reveals a pathway that, if deactivated, may help slow the development of the disease. "We have the ability to target this pathway with drugs that already exist,"...

2012-05-10 23:00:47

The human body does a great job of generating new cells to replace dead ones but it is not perfect. Cells need to communicate with or signal to each other to decide when to generate new cells. Communication or signaling errors in cells lead to uncontrolled cell growth and are the basis of many cancers. At The University of Texas Health Science Center at Houston (UTHealth) Medical School, scientists have made a key discovery in cell signaling that is relevant to the fight against melanoma...

2012-05-03 02:31:34

SEATTLE, May 3, 2012 /PRNewswire/ -- Omeros Corporation (NASDAQ: OMER) today announced that it has identified compounds that functionally interact with each of four additional orphan G protein-coupled receptors (GPCRs). Without compounds that functionally interact with orphan GPCRs, developing drugs targeting those receptors is extremely difficult. Omeros has now unlocked 37 of them, representing over 45 percent of the Class A orphan GPCRs. There are approximately 120 orphan GPCRs and Omeros...

2012-04-30 14:51:23

Berkeley Lab scientists demonstrate the promise of synchrotron infrared spectroscopy of living cells for medical applications Knowing how a living cell works means knowing how the chemistry inside the cell changes as the functions of the cell change. Protein phosphorylation, for example, controls everything from cell proliferation to differentiation to metabolism to signaling, and even programmed cell death (apoptosis), in cells from bacteria to humans. It´s a chemical process that...

2012-04-27 11:20:11

Bacteria provide a well-known playground for scientists and the evolution of these earliest life forms has shed important perspective on potential therapies for some of the most common, deadly diseases. Researchers at Case Western Reserve University School of Medicine have now discovered that, the gas nitric oxide (NO), produced in all cells of the human body for natural purposes, plays a fundamental regulatory role in controlling bacterial function, via a signaling mechanism called...

2012-04-24 12:37:03

A cellular protein called HDAC6, newly characterized as a gatekeeper of steroid biology in the brain, may provide a novel target for treating and preventing stress-linked disorders, such as depression and post-traumatic stress disorder (PTSD), according to research from the Perelman School of Medicine at the University of Pennsylvania. Glucocorticoids are natural steroids secreted by the body during stress. A small amount of these hormones helps with normal brain function, but their excess...

2012-04-23 11:16:47

Findings could lead to new therapies for stroke and epilepsy A key protein, which may be activated to protect nerve cells from damage during heart failure or epileptic seizure, has been found to regulate the transfer of information between nerve cells in the brain. The discovery, made by neuroscientists at the University of Bristol and published in Nature Neuroscience and PNAS, could lead to novel new therapies for stroke and epilepsy. The research team, led by Professor Jeremy Henley...

2012-04-19 10:40:57

A reaction to the antidepressant Zoloft that Princeton University researchers observed in yeast cells could help provide new answers to lingering questions among scientists about how antidepressants work, as well as support the idea that depression is not solely linked to the neurotransmitter serotonin. In findings published this week in PLoS ONE, researchers based in the lab of Ethan Perlstein, a research fellow in Princeton's Lewis-Sigler Institute for Integrative Genomics, report that...