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Last updated on April 23, 2014 at 16:13 EDT

Latest Cell signaling Stories

2012-04-17 06:27:48

OTTAWA, April 17, 2012 /PRNewswire/ - Health Canada today released the April 2012 issue of the Canadian Adverse Reaction Newsletter (CARN). This edition contains an article on a suspected association between the long-term use of the antibiotic minocycline for the treatment of acne in adolescents and two serious autoimmune disorders: drug-induced lupus erythematosus (a type of lupus), and autoimmune hepatitis (liver inflammation). It also includes an article on the painkiller fentanyl...

2012-04-12 22:25:16

Researchers at Boston University School of Medicine (BUSM) have identified a gene that plays a key role in regulating inflammatory response and homeostasis. These findings could help lead to the development of innovative methods to reduce the inflammation associated with cancer, type 2 diabetes and other diseases. The study, which was led by Valentina Perissi, PhD, assistant professor of biochemistry at BUSM, was done in collaboration with the Howard Hughes Medical Institute (HHMI) at the...

2012-04-03 09:09:25

Johns Hopkins investigators are testing a way to use drugs that target a cholesterol pathway to enhance the cancer-killing potential of standard chemotherapy drugs. Their tests, in mouse models of pancreatic cancer, may yield new and more effective combinations of current and possibly new anti-cancer drugs. Besides their deadly consequences, pancreatic cancer and heart disease share a connection with genetic pathways that control cholesterol and a cell signaling system known as the...

2012-04-02 21:07:54

Brown University biologists have found a new molecule in fruit flies that is key to the information exchange needed to build wings properly. They have also uncovered evidence that an analogous protein may exist in people and may be associated with problems such as cleft lip, or premature ovarian failure. As they work together to form body parts, cells in developing organisms communicate like workers at a construction site. The discovery of a new signaling molecule in flies by Brown...

2012-03-29 23:17:32

Proteins important in embryos found to change the adult brain Certain genes and proteins that promote growth and development of embryos also play a surprising role in sending chemical signals that help adults learn, remember, forget and perhaps become addicted, University of Utah biologists have discovered. "We found that these molecules and signaling pathways [named Wnt] do not retire after development of the organism, but have a new and surprising role in the adult. They are called...

2012-03-28 17:20:49

Later-stage cancers thrive by finding detours around roadblocks that cancer drugs put in their path, but a Purdue University biochemist is creating maps that will help drugmakers close more routes and develop better drugs. Kinase enzymes deliver phosphates to cell proteins in a process called phosphorylation, switching a cellular function on or off. Irregularities in phosphorylation can lead to uncontrolled cell growth and are a hallmark of cancer. Many successful cancer drugs are...

2012-03-20 11:19:01

Hedgehog and mTOR converge; Findings suggest new combination therapy Identification of a non-traditional pathway for spiriting a cancer-promoting protein into the cell nucleus points to a possible combination therapy for esophageal cancer and indicates a mechanism of resistance for new drugs that attack the Hedgehog pathway. A team of researchers at The University of Texas MD Anderson Cancer Center reports in the March 20 Cancer Cell that the mTOR molecular pathway promotes the activity...

2012-03-14 12:46:43

Since the mid-1990s, doctors have had the protein Mer in their sights — it coats the outside of cancer cells, transmitting signals inside the cells that aid their uncontrolled growth. A University of Colorado Cancer Center study, recently published in the journal PLoS ONE, found another home for Mer — inside cancer cells´ nuclei — and perhaps another role for this protein that can point the way to novel, targeted treatments. “We´ve known that leukemic B...

2012-03-08 15:52:48

The mechanism involved in the detection of hyperosmolarity by TRP channels is clarified, with a newly discovered molecule preventing apoptosis. A large change in the volume of a cell, from its basal level, is detrimental to its health. Therefore, our cells are equipped with mechanisms to maintain their constant volume. When a cell detects an environmental change that will alter its volume, due to changes in the osmotic pressure, it will adjust its internal water content...