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Latest Cell signaling Stories

2012-03-07 11:06:18

Do bacteria, like higher organisms, have a built-in program that tells them when to die? The process of apoptosis, or cell death, is an important part of normal animal development. In a new study published March 6 in the online, open-access journal PLoS Biology, Hanna Engelberg-Kulka and colleagues (at Hadassah Medical School of the Hebrew University, Jerusalem, Israel) have described for the first time a novel cell death pathway in bacteria that is similar to apoptosis in higher organisms....

2012-02-29 13:45:00

SANTA CLARA, Calif., Feb. 29, 2012 /PRNewswire/ -- ConfometRx, a leader in G protein coupled receptor (GPCR) structural characterization and analysis, is pleased to announce that it has expanded its service offerings to include generating iterative crystal structures of new GPCR targets as well as any GPCRs whose structures have been solved using T4-lysozyme (T4-L) fusion technology, and agonist structures using antibodies or G proteins to stabilize active states. The T4-L technology was...

2012-02-29 06:00:00

SEATTLE, Feb. 29, 2012 /PRNewswire/ -- Omeros Corporation (NASDAQ: OMER) today announced that it has identified compounds that functionally interact with each of the following six orphan G protein-coupled receptors (GPCRs): GPR17, GPR153, CCRL2, LGR4, LGR6 and OPN5. Without compounds that functionally interact with orphan GPCRs, developing drugs targeting those receptors is extremely difficult. Omeros has now unlocked 33 of them, representing over 40 percent of the Class A orphan...

2012-02-15 21:38:43

Researchers at Washington University School of Medicine in St. Louis have identified a potent regulator of sensitivity to insulin, the hormone that controls blood sugar levels. The new findings may help scientists find better treatments for type 2 diabetes, obesity and other health problems caused by the body´s inability to properly regulate blood sugar.   The research is published online Feb. 13 in PLoS ONE. Fat and muscle cells in patients with type 2 diabetes become...

2012-02-15 07:00:00

PENZBERG, Germany, February 15, 2012 /PRNewswire/ -- A research team led by Dr. Michel Bouvier at the Institute for Research in Immunology and Cancer (IRIC) of the University of Montreal in Quebec, used the Roche xCELLigence SP Instrument [https://www.roche-applied-science.com/sis/xcelligence/index.jsp?&id=xcect_030100 ] to measure changes in cell response following ligand stimulation (Stallaert et al., 2012, PloS ONE 7(1): e29420). According to their findings, selective...

2012-02-14 12:41:44

Researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch have now identified and described a molecular mechanism underlying the most common malformation of the brain in humans. In holoprosencephaly (HPE), the forebrain (prosencephalon) is only incompletely formed. Here a binding site (receptor) for cholesterol plays a key role. If this receptor is defective, specific signals cannot be received, and the forebrain cannot separate into two hemispheres, as...

Mouse Study Sheds Light On Controlling Hunger
2012-02-08 14:40:15

Researchers have revealed that the neural circuits controlling hunger and eating behaviors are also controlled by plasticity. They found that during fasting, the AgRP neurons that drive feeding behaviors actually undergo anatomical changes that cause them to become more active. This effect results in these neurons "learning" to be more responsive to hunger-promoting neural stimuli. "The role of plasticity has generally not been evaluated in neuronal circuits that control feeding...

2012-02-01 23:36:46

Using some of the most powerful nuclear magnetic resonance equipment available, researchers at the University of California, Davis, are making discoveries about the shape and structure of biological molecules -- potentially leading to new ways to treat or prevent diseases such as breast cancer and Alzheimer's disease. The findings appear in the latest issues of the journals Nature and Journal of Biological Chemistry. "These are exquisite three-dimensional objects, and the structures...

2012-01-24 11:47:32

Study of plant hormone could have far-reaching implications for cell biology and disease research A recent Van Andel Research Institute (VARI) study published in the journal Science investigating the molecular structure and function of an essential plant hormone could profoundly change our understanding of a key cell process, and might ultimately lead to the development of new drugs for a variety of diseases. The study builds on earlier work by the same team of investigators at VARI...

2012-01-24 10:43:55

Study of plant hormone could have far-reaching implications for cell biology and disease research A recent Van Andel Research Institute (VARI) study published in the journal Science investigating the molecular structure and function of an essential plant hormone could profoundly change our understanding of a key cell process, and might ultimately lead to the development of new drugs for a variety of diseases. The study builds on earlier work by the same team of investigators at VARI...