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Latest Cell signaling Stories

2012-03-14 12:46:43

Since the mid-1990s, doctors have had the protein Mer in their sights — it coats the outside of cancer cells, transmitting signals inside the cells that aid their uncontrolled growth. A University of Colorado Cancer Center study, recently published in the journal PLoS ONE, found another home for Mer — inside cancer cells´ nuclei — and perhaps another role for this protein that can point the way to novel, targeted treatments. “We´ve known that leukemic B...

2012-03-08 15:52:48

The mechanism involved in the detection of hyperosmolarity by TRP channels is clarified, with a newly discovered molecule preventing apoptosis. A large change in the volume of a cell, from its basal level, is detrimental to its health. Therefore, our cells are equipped with mechanisms to maintain their constant volume. When a cell detects an environmental change that will alter its volume, due to changes in the osmotic pressure, it will adjust its internal water content...

2012-03-07 11:06:18

Do bacteria, like higher organisms, have a built-in program that tells them when to die? The process of apoptosis, or cell death, is an important part of normal animal development. In a new study published March 6 in the online, open-access journal PLoS Biology, Hanna Engelberg-Kulka and colleagues (at Hadassah Medical School of the Hebrew University, Jerusalem, Israel) have described for the first time a novel cell death pathway in bacteria that is similar to apoptosis in higher organisms....

2012-02-15 21:38:43

Researchers at Washington University School of Medicine in St. Louis have identified a potent regulator of sensitivity to insulin, the hormone that controls blood sugar levels. The new findings may help scientists find better treatments for type 2 diabetes, obesity and other health problems caused by the body´s inability to properly regulate blood sugar.   The research is published online Feb. 13 in PLoS ONE. Fat and muscle cells in patients with type 2 diabetes become...

2012-02-14 12:41:44

Researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch have now identified and described a molecular mechanism underlying the most common malformation of the brain in humans. In holoprosencephaly (HPE), the forebrain (prosencephalon) is only incompletely formed. Here a binding site (receptor) for cholesterol plays a key role. If this receptor is defective, specific signals cannot be received, and the forebrain cannot separate into two hemispheres, as...

Mouse Study Sheds Light On Controlling Hunger
2012-02-08 14:40:15

Researchers have revealed that the neural circuits controlling hunger and eating behaviors are also controlled by plasticity. They found that during fasting, the AgRP neurons that drive feeding behaviors actually undergo anatomical changes that cause them to become more active. This effect results in these neurons "learning" to be more responsive to hunger-promoting neural stimuli. "The role of plasticity has generally not been evaluated in neuronal circuits that control feeding...

2012-02-01 23:36:46

Using some of the most powerful nuclear magnetic resonance equipment available, researchers at the University of California, Davis, are making discoveries about the shape and structure of biological molecules -- potentially leading to new ways to treat or prevent diseases such as breast cancer and Alzheimer's disease. The findings appear in the latest issues of the journals Nature and Journal of Biological Chemistry. "These are exquisite three-dimensional objects, and the structures...


Word of the Day
Cthulhu
  • A gigantic fictional humanoid alien god being described with a head resembling an octopus and dragon wings and claws, around whom an insane cult developed.
  • Pertaining to the mythos of Cthulhu and additional otherworldly beings created by H. P. Lovecraft or inspired by his writings and imitators.
This word was invented in 1926 by H.P. Lovecraft for his short story, 'The Call of Cthulhu.' 'Cthulhu' may be based on the word 'chthonic,' which in Greek mythology refers to the underworld.
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