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Last updated on April 24, 2014 at 17:35 EDT

Latest Cell signaling Stories

2013-05-01 12:34:12

St. Jude Children's Research Hospital advances understanding of how T cells craft an appropriate immune response; setting the stage for new strategies to intervene if the system goes awry A properly functioning immune system is a lesson in balance, providing protection against disease without attacking healthy tissue. Work led by St. Jude Children's Research Hospital scientists and published recently in Nature Immunology has identified a mechanism that helps T cells find that sweet spot...

2013-04-22 22:29:32

A three-dimensional image of one of the proteins that serves as an on-off switch as it binds to receptors on the surface of a cell suggests there may be a sort of main power switch that could be tripped. These surface receptors are responsible for helping cells discern light, set the heart racing, or detect pain. The finding, published online April 21, 2013, in the journal Nature by a research collaboration involving this year's Nobel laureates in chemistry, could help in the development...

2013-04-22 14:18:26

Union with Shc keeps potential troublemaker away from bad company and out of the nucleus A protein which is intimately involved in cancer-promoting cell signaling also keeps a key component of the signaling pathway tied down and inactive, a team led by scientists from The University of Texas MD Anderson Cancer Center reports this week in Nature Structural Molecular Biology. Shc, pronounced "schick," plays a key role in activating signals which lead to cell proliferation (and cancer)...

2013-04-17 11:40:49

Spread of breast cancer linked to kisspeptins which normally inhibit metastasis KISS 1 is a metastasis-suppressor gene which helps to prevent the spread of cancers, including melanoma, pancreatic and ovarian cancers to name a few. But new research from Western University's Schulich School of Medicine & Dentistry shows that kisspeptins —peptide products of KISS1, actually make some breast cancers worse, with a higher tumor grade and metastatic potential. The research is published...

2013-04-16 08:28:14

WELWYN GARDEN CITY, England and BOSTON, April 16, 2013 /PRNewswire/ -- Heptares Therapeutics, the leading GPCR drug discovery company, notes that it will be presenting at the following scientific conferences and biotech industry events over the coming weeks. 8th Annual Drug Discovery Chemistry [http://www.drugdiscoverychemistry.com/GPCR-Drug-Design ] (San Diego, CA, USA, April 16-18) Dr Rob Cooke, Heptares' Head of Biomolecular Structure, will give a presentation...

Retinoic Acid Gradient Observed For The First Time In A Zebrafish Embryo
2013-04-08 13:31:35

RIKEN In a ground-breaking study, researchers from the RIKEN Brain Science Institute in Japan report a new technique that allows them to visualize the distribution of retinoic acid in a live zebrafish embryo, in real-time. This technique enabled them to observe two concentration gradients going in opposing directions along the head-to-tail axis of the embryo, thus providing long-awaited evidence that retinoic acid is a morphogen. The report, published today in the journal Nature, puts...

IntegrinMD
2013-03-22 16:03:48

Lawrence Berkeley National Laboratory Your cells are social butterflies. They constantly interact with their surroundings, taking in cues on when to divide and where to anchor themselves, among other critical tasks. This networking is driven in part by proteins called integrin, which reside in a cell´s outer plasma membrane. Their job is to convert mechanical forces from outside the cell into internal chemical signals that tell the cell what to do. That is, when they work properly....

2013-03-22 09:39:00

A team including scientists from The Scripps Research Institute (TSRI), the University of North Carolina at Chapel Hill and the Chinese Academy of Sciences has determined and analyzed the high-resolution atomic structures of two kinds of human serotonin receptor. The new findings help explain why some drugs that interact with these receptors have had unexpectedly complex and sometimes harmful effects. "Understanding the structure-function of these receptors allows us to discover new...

2013-03-14 12:27:46

IRVINE, Calif., March 14, 2013 /PRNewswire/ -- GeneTex, a leading manufacturer of high-quality antibodies, is pleased to announce that it will be launching new antibodies against phosphorylated Histone H2A.X and p53 designed for use with zebrafish samples. (Photo: http://photos.prnewswire.com/prnh/20111129/LA13485LOGO-b) The zebrafish is being increasingly utilized as a model organism to study DNA repair. The zebrafish genome contains nearly all of the genes involved in the different DNA...

2013-03-12 00:20:48

TOKYO and SAN DIEGO, March 12, 2013 /PRNewswire/ -- Astellas Pharma Inc. (Astellas) (Tokyo: 4503) and Ambit Biosciences Corporation today announced the companies will end their collaboration for the joint development and commercialization of FMS-like tyrosine kinase-3 (FLT3) inhibitors, including quizartinib, effective September 3, 2013. Astellas has exercised its right to terminate the worldwide license agreement signed in 2009, and over the months ahead the companies will work together to...