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Latest Cellular processes Stories

2011-10-24 10:15:15

Findings suggest how cancer cells can become resistant to DNA damage-inducing treatments An international team of scientists led by UC Davis researchers has discovered that DNA repair in cancer cells is not a one-way street as previously believed. Their findings show instead that recombination, an important DNA repair process, has a self-correcting mechanism that allows DNA to make a virtual u-turn and start over. The study's findings, which appear in the Oct. 23 online issue of the...

2011-10-10 09:07:53

All cells in our body have a system that can handle cellular waste and release building blocks for recycling. The underlying mechanism is called autophagy and literally means "self-eating". Many cancer cells have increased the activity of this system and the increased release of building blocks equip the cancer cells with a growth advantage and can render them resistant towards treatment. "We have discovered a small molecule that can block autophagy in different cancer cells and...

2011-10-07 13:50:00

Ascent Scientific, together with Freie Universität Berlin, The University of Newcastle and Children's Medical Research Institute today announced that they have entered into an exclusive licence, supply and distribution agreement for the clathrin inhibitors Pitstop 1TM and Pitstop 2TM for research. These novel compounds are the first rationally designed inhibitors of clathrin, and represent important tools for investigating essential cellular processes such as endocytosis. The agreement...

2011-10-06 13:08:46

In children with genomic disorders, often a gamete — egg or sperm — has gone disastrously awry with either a duplication or deletion of genetic material that results in physical and neurological problems for the subsequent child. Previous studies have identified a procedure called nonallelic homologous recombination, which occurs during meiosis or sexual cell division, as the event that most commonly occurs and results in this mistake in DNA. Researchers from Baylor College...

2011-09-20 13:41:22

Dr. Katja Fälber and Professor Oliver Daumke, structural biologists at the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, together with researchers from Freie Universität (FU) Berlin, have determined the molecular structure of dynamin, a ℠wire-puller´ that mediates nutrient uptake into the cell. Since pathogens such as HIV can also enter the body´s cells in this way, understanding the underlying molecular mechanisms...

2011-09-20 12:36:26

Although the body is constantly replacing cells and cell constituents, damage and imperfections accumulate over time. Cleanup efforts are saved for when it really matters. Researchers from the University of Gothenburg, Sweden, are able to show how the body rids itself of damage when it is time to reproduce and create new life. 'I have a daughter. She is made of my cells yet has much less cellular damage than my cells. Why didn't she inherit my cells including the damaged proteins? That's...

2011-09-19 07:33:36

The crystal structure of the dynamin protein – one of the molecular machines that makes cells work – has been revealed, bringing insights into a class of molecules with a wide influence on health and disease. "It's a really cool structure," said Jodi Nunnari, professor and chair of molecular and cellular biology at UC Davis and senior author of the paper, to be published Sept. 18 in the journal Nature. "This is a really important class of molecules for regulating membrane...

2011-09-08 20:54:30

Researchers at the California Institute of Technology (Caltech) have obtained the first high-resolution, three-dimensional images of a cell with a nucleus undergoing cell division. The observations, made using a powerful imaging technique in combination with a new method for slicing cell samples, indicate that one of the characteristic steps of mitosis is significantly different in some cells. During mitosis, two sets of chromosomes get paired up at the center of the cell's nucleus. Then...

2011-09-06 22:13:37

Sanford-Burnham researchers unravel how the interplay between two cellular processes–autophagy and lipid metabolism–influences lifespan in C. elegans worms Aging is generally accepted as a universal fact of life, but how do humans and other organisms age at the molecular level? At Sanford-Burnham Medical Research Institute (Sanford-Burnham), a team led by Malene Hansen, Ph.D., uses a type of worm called Caenorhabditis elegans to work out the molecular underpinnings of the aging...

2011-09-01 16:40:08

Just as we must take out the trash to keep our homes clean and safe, it is essential that our cells have mechanisms for dealing with wastes and worn-out proteins. When these processes are not working properly, unwanted debris builds up in the cell and creates a toxic environment. Now, a new study published by Cell Press on September 1st in the journal Developmental Cell describes a master regulator of the intracellular recycling and waste removal process and suggests an alternative strategy...


Word of the Day
holluschickie
  • A 'bachelor seal'; a young male seal which is prevented from mating by its herd's older males (mated bulls defending their territory).
This comes from the Russian word for 'bachelors.'
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