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Latest Center for Applied Genomics Stories

2014-08-12 12:43:17

Children's Hospital of Philadelphia CHOP expert, collaborators among first to use molecular genetic approach to evaluate complex traits in children's intelligence How genes affect intelligence is complicated. Multiple genes, many yet unknown, are thought to interact among themselves and with environmental factors to influence the diverse abilities involved in intelligence. A large new genetic study in thousands of children and adolescents offers early glimpses of the overall...

2014-06-30 12:32:32

--CHOP Study: Patients with Specific Gene Variants May Require Higher Doses of Pain-Control Drugs-- PHILADELPHIA, June 30, 2014 /PRNewswire-USNewswire/ -- In the first genome-wide analysis of postsurgical pain in children, pediatric researchers identified variations in genes that affect a child's need for pain-control drugs. The findings suggest that at some point physicians may calibrate pain-medication dosages according to a child's individual genetic makeup....

Childhood Asthma Caused By Specific Genetic Variant
2013-11-18 05:13:02

redOrbit Staff & Wire Reports - Your Universe Online An international team of scientists has identified the primary genes that place some children at high risk of severe childhood asthma, according to research published Sunday in the journal Nature Genetics. Dr. Klaus Bønnelykke, a senior researcher at the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), the Danish Pediatric Asthma Center, Copenhagen University Hospital, and his colleagues believe that the specific...

2013-10-18 13:26:56

A gene important in skin tanning has been linked to higher risk for testicular cancer in white men, according to a study led by scientists from the U.S. National Institutes of Health and the University of Oxford in England. Nearly 80 percent of white men carry a variant form of this gene, which increased risk of testicular cancer up to threefold in the study. The research appeared online October 10, 2013 in the journal Cell, and is the result of an integrated analysis of big data supported...

2013-09-30 12:53:40

Brings to 110 known risk factors and provides important insight into disease mechanism Scientists of the International Multiple Sclerosis Genetics Consortium (IMSGC) have identified an additional 48 genetic variants influencing the risk of developing multiple sclerosis. This work nearly doubles the number of known genetic risk factors and thereby provides additional key insights into the biology of this debilitating neurological condition. The genes implicated by the newly identified...

2013-02-05 10:30:49

CHOP researchers compared young to old populations, identified CNVs conferring long-term risk or protection By broadly comparing the DNA of children to that of elderly people, gene researchers have identified gene variants that influence lifespan, either by raising disease risk or by providing protection from disease. "This research is the first genome-wide, population-based study of copy number variations in children associated with human longevity," said study leader Hakon Hakonarson,...

2013-01-21 10:27:56

CHOP researcher leads large multicenter gene sequencing study of neuroblastoma An extensive genomic study of the childhood cancer neuroblastoma reinforces the challenges in treating the most aggressive forms of this disease. Contrary to expectations, the scientists found relatively few recurrent gene mutations–mutations that would suggest new targets for neuroblastoma treatment. Instead, say the researchers, they have now refocused on how neuroblastoma tumors evolve in response to...

Gene Variants In Autistic Patients Identified
2013-01-15 18:33:10

Lee Rannals for redOrbit.com — Your Unvierse Online Researchers wrote in the journal PLOS ONE they have identified 25 additional copy number variations (CNVs) which occur in some patients with autism. These CNVs are "high impact," and although they are individually rare, each one has a strong effect in raising an individual's risk for autism. "Many of these gene variants may serve as valuable predictive markers," the study's corresponding author, Hakon Hakonarson, MD, PhD,...


Word of the Day
caparison
  • A cloth or covering, more or less ornamented, laid over the saddle or furniture of a horse, especially of a sumpter-horse or horse of state.
  • Clothing, especially sumptuous clothing; equipment; outfit.
  • To cover with a caparison, as a horse.
  • To dress sumptuously; adorn with rich dress.
This word ultimately comes from the Medieval Latin 'cappa,' cloak.
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