Latest Centromere Stories
Biological species are often defined on the basis of reproductive isolation.
The Stowers Institute's Gerton Lab has provided new evidence to clarify the structure of nucleosomes containing Cse4, a centromere-specific histone protein required for proper kinetochore function, which plays a critical role in the process of mitosis.
The unique mechanism behind the evolutionary survival of the human Y chromosome may also be responsible for a range of sex disorders, from failed sperm production to sex reversal to Turner Syndrome.
Lars Jansen's work on the formation of the centromere, a key cellular structure in powering and controlling chromosome segregation and accurate cell division.
The DNA in the 23 pairs of chromosomes in each of the billions of cells of the human body is so tightly packed that it would measure six feet in length if stretched end to end.
- GlaxoSmithKline continues to lead development activities for GSK-923295 LONDON, Dec.
Cytokinetics, Incorporated (NASDAQ: CYTK) announced today that three posters containing data on GSK-923295, an inhibitor of centromere-associated protein E (CENP-E), and one poster containing data on SB-743921, an inhibitor of kinesin spindle protein (KSP), were presented at the 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics held at the Geneva Palexpo, Geneva, Switzerland.
Breakages in chromosomes in mammalian evolution have occurred at preferred rather than random sites as long thought, and many of the sites are involved in human cancers, an international team of 25 scientists has discovered.
Dr. Craig Peterson and colleagues have identified an S. pombe ubiquitin ligase that is required for heterochromatin formation and gene silencing. The authors purified the heterochromatin assembly protein, Rik1, along with two novel Rik-1 associated proteins that proved essential for H3-K9 methylation and centromere silencing. Intruigingly, they also found a novel Rik1-associated E3 ligase that is necessary for heterochromatin assembly.
Scientists document temporal bias in gene duplication events for a complex region of human chromosome 2.