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Last updated on April 19, 2014 at 12:41 EDT

Latest Channelopathy Stories

2008-07-08 09:01:11

FoldRx Pharmaceuticals, Inc. (FoldRx) today announced that it has discovered a series of novel drug prototypes that have shown potential in vitro to correct the protein-folding defect associated with cystic fibrosis (CF). The discovery, made through a research collaboration announced last year with Cystic Fibrosis Foundation Therapeutics, Inc. (CFFT), the nonprofit affiliate of the Cystic Fibrosis Foundation, may pave the way to novel drugs capable of repairing the protein misfolding...

2008-06-30 15:03:02

Case Western Reserve University School of Medicine, in collaboration with Copernicus Therapeutics, Inc. and Polgenix, Inc., was selected to receive $3.9 million in funding from the Ohio Biomedical Research Commercialization Program (BRCP) as awarded by Lieutenant Governor Lee Fisher, Chair of the Ohio Third Frontier Commission. The BRCP awards grants that support Ohio-based biomedical and biotechnology research leading to commercialization and long-term improvements to the health of...

2008-06-30 09:02:20

Aradigm Corporation (OTCBB:ARDM) (the "Company") today announced positive results from an open-label, two week efficacy and safety study of its once daily inhaled liposomal ciprofloxacin in patients with cystic fibrosis (CF). The study conducted at leading CF centers in Australia and New Zealand enrolled a total of 22 patients. The primary efficacy endpoint in this Phase 2 study was the change from baseline in the sputum Pseudomonas Aeruginosa colony forming units (CFU), an objective...

2008-06-26 06:02:10

By Knott, Laurence THE BASICS Proactive management can improve patient survival. By Dr Laurence Knott Cystic fibrosis (CF) affects one in 2,500 newborns and has a UK prevalence of 8,000. It is the most common inherited condition in white populations, and is increasingly recognised in non-white populations. CF is an autosomal recessive disorder caused by a mutation at the CF transmembrane conductance regulator gene that affects various cellular activities. These include transport of...

2008-06-16 12:01:05

Altus Pharmaceuticals has announced the completion of the last patient visit of the Trizytek Phase III efficacy trial. In this trial, Altus is evaluating the efficacy of an oral, non-porcine enzyme replacement therapy for cystic fibrosis patients with exocrine pancreatic insufficiency. The Digest efficacy trial tested a one capsule per-meal dosing regimen and will study fat, protein and carbohydrate absorption in cystic fibrosis patients with exocrine pancreatic insufficiency. In...

2008-06-14 06:00:00

By Anonymous CYSTIC FIBROSIS Cystic fibrosis is the most common genetic disease in Caucasians. The median life span for those with this malady is 36 years, and lung disease is the major cause of mortality. For years, scientists have studied cystic fibrosis using mice in which the cystic fibrosis gene was altered. However, mice do not develop lung disease like humans with cystic fibrosis. Researchers at the University of Missouri, Columbia, and the University of Iowa, Iowa City, have taken...

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2008-04-07 10:00:00

U.S. researchers say up to 100 million people globally have genetic mutations that keep their blood pressure low and lower their risk of heart and kidney disease and stroke.These findings could help scientists design new and better blood pressure drugs, as well as shed some light on how the kidneys handle salt and regulate blood pressure.Richard Lifton, a Howard Hughes Medical Institute researcher at Yale University in Connecticut, said these mutation carriers have a 60 percent reduction in...

2007-06-14 06:07:57

By Papantoniou, Nicolaos Katsoulis, Ioannis; Papageorgiou, Ioannis; Antsaklis, Aris Abstract Long QT syndrome is a rare but severe cardiac arrhythmia. We report the antenatal and intrapartum management of a primigravida carrying the hereditary form of the disease and specifically the Romano-Ward syndrome. A multidisciplinary approach and close obstetric surveillance are mandatory for a good maternal and perinatal outcome. Follow-up of the neonate is equally important. Keywords: Hereditary...

2007-06-04 12:00:42

Copernicus Therapeutics, Inc. announced today that a research team at University of Oklahoma Health Sciences Center, led by Dr. Muna Naash, Professor of Cell Biology, demonstrated that Copernicus' DNA nanoparticles corrected vision defects in a mouse model of retinitis pigmentosa (RP). These findings were presented at the American Society of Gene Therapy meeting in Seattle, WA. Mutations in genes important in the biology of vision cause RP, a common genetic form of visual impairment...

2006-12-03 18:00:11

By RACHEL AGUTTER; VICTORIA LAMBERT Like the Browns' baby, Jenny Agutter's niece has cystic fibrosis. But her defiant words and joyful pictures prove that she can still live life to the full At 28, Rachel Agutter has lived with cystic fibrosis all her life. Here, in her own inspirational words, she describes how she has never let the disease stop her enjoying life to the full. And on the following page, her aunt, Railway Children star Jenny Agutter, tells of the latest treatments and...


Latest Channelopathy Reference Libraries

Cystic Fibrosis
2013-07-19 15:03:45

Cystic fibrosis, also called mucoviscidosis, is an autosomal recessive genetic disorder of the viscous secretions in the body. In turn, it effects the lungs, pancreas, liver, and intestines, as well as all other exocrine glands in the body. The most common genetic mutation that causes CF is a deletion of three nucleotides that results in a loss of phenylalanine, an amino acid at the 508th position on the protein. It should be noted, however, that there are over a thousand other mutations that...

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