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Latest Chaperone Stories

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2014-07-20 10:59:47

Tracey Bryant, University of Delaware University of Delaware researchers have identified a protein, hiding in plain sight, that acts like a bodyguard to help protect and stabilize another key protein, that when unstable, is involved in Crohn’s disease. The fundamental research points to a possible pathway for developing an effective therapy for the inflammatory bowel disease. The research, by Catherine Leimkuhler Grimes, assistant professor of chemistry and biochemistry at UD, and...

Researchers Discover Achilles Heel Of The Plasmodium And Aim A Molecular Arrow To Destroy It
2014-03-12 15:01:18

Université de Genève The malaria parasite is particularly pernicious since it is built to develop resistance to treatments. The lack of new therapeutic approaches also contributes to the persistence of this global scourge. A study led by Didier Picard, professor at the Faculty of Sciences of the University of Geneva (UNIGE), Switzerland, describes a new class of molecules targeting the two problems at the same time. Using ultra sophisticated computerised modelling tools, the researchers...

Connection Among Protein Misfolding, Sleep Loss, And Age Strengthened By Fruit Fly Study
2014-02-21 13:16:54

University of Pennsylvania School of Medicine Pulling an "all-nighter" before a big test is practically a rite of passage in college. Usually, it's no problem: You stay up all night, take the test, and then crash, rapidly catching up on lost sleep. But as we age, sleep patterns change, and our ability to recoup lost sleep diminishes. Researchers at the Perelman School of Medicine, University of Pennsylvania, have been studying the molecular mechanisms underpinning sleep. Now they report...

2013-12-06 15:08:40

Findings by UCI, German researchers could aid in saving sight of millions Groundbreaking new findings by UC Irvine and German chemists about how cataracts form could be used to help prevent the world’s leading cause of blindness, which currently affects nearly 20 million people worldwide. “That’s the dream, and this is a big step,” said Rachel Martin, UC Irvine associate professor of chemistry and co-author of a paper featured on the December cover of the journal Structure....

2013-10-01 15:33:50

Scientists at the University of Wisconsin-Madison have made a discovery that, if replicated in humans, suggests a shortage of zinc may contribute to diseases like Alzheimer's and Parkinson's, which have been linked to defective proteins clumping together in the brain. With proteins, shape is everything. The correct shape allows some proteins to ferry atoms or molecules about a cell, others to provide essential cellular scaffolding or identify invading bacteria for attack. When proteins...

Stress-related Protein Increases Progression Of Alzheimer’s Disease
2013-09-04 10:59:51

[ Watch The Video - Untangling the Brain ] University of South Florida USF-led study suggests FKBP51 is a new treatment target for diseases with tau pathology A stress-related protein genetically linked to depression, anxiety and other psychiatric disorders contributes to the acceleration of Alzheimer’s disease, a new study led by researchers at the University of South Florida has found. The study is published online today in the Journal of Clinical Investigation. When...

Chaperone Protein Subverts Removal Of Glaucoma-causing Protein
2012-10-09 15:53:46

Inhibiting the protein, Grp94, could offer new treatment for the sight-robbing eye disease The chaperone protein Grp94 can interfere with the clearance of another protein known to cause the glaucoma when mutated, a new study led by researchers at the University of South Florida has found. Using a cell model, the researchers also demonstrated that a new specific inhibitor of Grp94 facilitates clearance of the genetically-defective protein, called myocilin, from cells. Reported online...

2012-06-20 11:13:47

Amyloid fibers in the brain are a hallmark of many neurodegenerative diseases, including Parkinson's disease, for which there are no effective treatments. These fibers result from aggregation of a specific protein in each disease–in Parkinson's, for example, the aggregated protein is called alpha-synuclein. Although amyloid fibers are implicated in numerous pathologies, they can also play beneficial, protective roles. In yeast, for example, they are associated with increased survival...

2012-06-11 21:50:23

Researchers work to untangle knots, slipknots in species separated by a billion years of evolution Strings of all kinds, when jostled, wind up in knots. It turns out that happens even when the strings are long strands of molecules that make up proteins. A new study by scientists at Rice University and elsewhere examines structures of proteins that not only twist and turn themselves into knots, but also form slipknots that, if anybody could actually see them, might look like shoelaces...


Word of the Day
caparison
  • A cloth or covering, more or less ornamented, laid over the saddle or furniture of a horse, especially of a sumpter-horse or horse of state.
  • Clothing, especially sumptuous clothing; equipment; outfit.
  • To cover with a caparison, as a horse.
  • To dress sumptuously; adorn with rich dress.
This word ultimately comes from the Medieval Latin 'cappa,' cloak.
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