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Latest Chaperone Stories

2010-06-18 01:27:53

Scientists watch as E. coli bacteria evolve heat resistance under stress Scientists in Munich report evidence that high concentrations of the molecular "chaperone" proteins GroEL and GroES -- intracellular machines that can stabilize folding proteins under stress -- play a critical role in increasing the maximum temperature at which E. coli bacteria can grow. Massively and permanently elevated levels of the GroE proteins were found in bacteria adapted, step-wise over a period of years, for...

2010-05-24 08:00:00

LOS ANGELES, May 24 /PRNewswire/ -- WWE Studios has acquired "THE CHAPERONE," by playwright turned screenwriter S. J. Roth. This is the first screenplay sale for Roth who is mostly known for his work on stage, including his off-Broadway and West Coast productions of "SUTTON," the story of legendary bank robber, Willie Sutton, and comedies "BEN THE PRINTER," and "BONNIE'S WANTED MAN." "THE CHAPERONE" is a kids action comedy about a just released, ex-con dad who unwittingly becomes a...

2010-02-03 22:35:11

Medical College of Georgia researchers are seeking to refine cancer treatment with an anti-inflammatory plant derivative long used in Chinese medicine. Celastrol, derived from trees and shrubs called celastracaea, has been used for centuries in China to treat symptoms such as fever, chills, joint pain and inflammation. The MCG researchers think it may also play a role in cancer treatment by inactivating a protein required for cancer growth. That protein, P23, is one of many proteins helping...

2010-01-26 15:18:12

Contrary to prevailing wisdom, a new study from plant biologists at UC Davis shows that proteins of the Hsp70 family do indeed chaperone proteins across the membranes of chloroplasts, just as they do for other cellular structures. The findings are published online in the January issue of the journal The Plant Cell. One of the most crucial tasks in a living cell is to move things across membranes, both in and out of the cell and between different compartments inside. Chloroplasts are...

2010-01-20 14:59:50

In proper society of yesterday, a chaperone ensured that couples maintained appropriate courting rituals. In biology, a group of proteins called chaperonins make sure that proteins are folded properly to carry out their assigned roles in the cells. In a new study in archaea (single-celled organisms without nuclei to enclose their genetic information), a consortium of researchers from Baylor College of Medicine and Stanford University in California discovered how the Group II chaperonins close...

2010-01-20 13:14:32

Scientists at Duke University Medical Center have found some compounds that improve a cell's ability to properly "fold" proteins and could lead to promising drugs for degenerative nerve diseases, including Huntington's disease, Alzheimer's disease and Parkinson's disease. Misfolded proteins in nerve cells (neurons) are a common factor in all of these diseases. The Duke team has identified many new chemicals that activate a master regulator to increase the supply of "protein chaperone"...

2010-01-15 17:35:50

Proteosome inhibitors can rescue mutant proteins without altering the DNA of mutant genes Researchers at Fox Chase Cancer Center have demonstrated how it could be possible to treat genetic diseases by enhancing the natural ability of cells to restore their own mutant proteins. In particular, they found that drugs called proteosome inhibitors could provide one way of manipulating cells into producing more of a so-called chaperone protein, named Hsp70, which helps amino acid chains fold into...

2009-12-28 17:03:39

Just like teenagers at a prom, proteins are tended by chaperones whose job it is to prevent unwanted interactions among immature clients. And at the molecular level, just as at the high school gym level, it's a job that usually requires a lot of energy. In new research, scientists at the University of Michigan and Howard Hughes Medical Institute have discovered how a protein chaperone called HdeA, which helps protect bacteria like the notorious Escherichia coli from the ravages of stomach...

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2009-12-02 13:14:11

Physicians should not respond to amorous advances from patients on social networking sites like Facebook, according to the Medical Defense Union (MDU), a British association that provides legal advice and support to doctors, Reuters reported. The MDU, which calls itself the UK's leading medical defense organization, said it is aware of a number of cases where patients have attempted to proposition doctors by sending them an unsolicited message on Facebook or similar sites. "Responding to...

2009-11-26 14:24:55

Crystal structure shows how drug disables harmful copper in cells The copper sequestering drug tetrathiomolybdate (TM) has been shown in studies to be effective in the treatment of Wilson disease, a disease caused by an overload of copper, and certain metastatic cancers. That much is known. Very little, however, is known about how the drug works at the molecular level. A new study led by Northwestern University researchers now has provided an invaluable clue: the three-dimensional structure...


Word of the Day
bibliopole
  • A bookseller; now, especially, a dealer in rare and curious books.
This word comes from a Greek phrase meaning 'book seller.'
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