Latest Chaperone Stories
The copper sequestering drug tetrathiomolybdate (TM) has been shown in studies to be effective in the treatment of Wilson disease, a disease caused by an overload of copper, and certain metastatic cancers. That much is known. Very little, however, is known about how the drug works at the molecular level.
Like yoga for office drones, cells do have coping strategies for stress. Heat, lack of nutrients, oxygen radicals â€“ all can wreak havoc on the delicate internal components of a cell, potentially damaging it beyond repair.
Laboratory study shows drug targets chaperone Hsp70 to reduce Alzheimer's protein.
The human eye lens consists of a highly concentrated mix of several proteins. Protective proteins prevent these proteins from aggregating and clumping. If this protective function fails, the lens blurs and the patient develops cataracts.
Dissecting how heat shock protein 90 gets steroid receptors into shape to use hormones like estrogen and testosterone could lead to targeted therapies for hormone-driven cancers, such as breast and prostate, that need them as well, Medical College of Georgia researchers say.
Researchers at Fox Chase Cancer Center have demonstrated that it might be possible to treat genetic diseases, including some forms of cancer, by "rescuing" the misshapen, useless proteins produced by some mutant genes.
The potential of the appetite suppressing hormone -- leptin -- may be realized after all, U.S.
Exelixis, a development-stage biotechnology company, has submitted an investigational new drug application to the FDA for XL888, a novel anticancer compound.
Exelixis, Inc. (Nasdaq:EXEL) announced today that it has submitted an investigational new drug (IND) application to the U.S. Food and Drug Administration for XL888, a novel anticancer compound.
CytRx Corporation (Nasdaq:CYTR), a biopharmaceutical research and development company engaged in the development of high-value human therapeutics, today announced the completion of its acquisition of Innovive Pharmaceuticals, Inc.
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