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Latest Chaperone Stories

2009-11-26 14:24:55

Crystal structure shows how drug disables harmful copper in cells The copper sequestering drug tetrathiomolybdate (TM) has been shown in studies to be effective in the treatment of Wilson disease, a disease caused by an overload of copper, and certain metastatic cancers. That much is known. Very little, however, is known about how the drug works at the molecular level. A new study led by Northwestern University researchers now has provided an invaluable clue: the three-dimensional structure...

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2009-10-30 10:00:29

Like yoga for office drones, cells do have coping strategies for stress. Heat, lack of nutrients, oxygen radicals "“ all can wreak havoc on the delicate internal components of a cell, potentially damaging it beyond repair. Proteins called HSPs (heat shock proteins) allow cells to survive stress-induced damage. Scientists have long studied how HSPs work in order to harness their therapeutic potential. Donna George, PhD, Associate Professor of Genetics, and Julie Leu, PhD, Assistant...

2009-09-30 10:55:31

Laboratory study shows drug targets chaperone Hsp70 to reduce Alzheimer's protein Inhibiting the protein Hsp70 rapidly reduces brain levels of tau, a protein associated with Alzheimer's disease when it builds up abnormally inside nerve cells affecting memory, neuroscientists at the University of South Florida found. The study is reported online Sept. 29 in the Journal of Neuroscience. "Now that we've discovered that targeting the chaperone protein Hsp70 can clear tau, it could be helpful in...

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2009-07-31 09:45:00

The human eye lens consists of a highly concentrated mix of several proteins. Protective proteins prevent these proteins from aggregating and clumping. If this protective function fails, the lens blurs and the patient develops cataracts. Two research groups at the Department of Chemistry of the Technische Universitaet Muenchen (TUM) have succeeded in explaining the molecular architecture of this kind of protective protein. Their findings, which are published online in the current early...

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2009-06-22 11:00:00

 Dissecting how heat shock protein 90 gets steroid receptors into shape to use hormones like estrogen and testosterone could lead to targeted therapies for hormone-driven cancers, such as breast and prostate, that need them as well, Medical College of Georgia researchers say."We are trying to understand how Hsp90 folds steroid receptors into the proper conformation so they work," says Dr. Ahmed Chadli, biochemist in the MCG Center for Molecular Chaperones/Radiobiology and Cancer...

2009-02-13 10:03:00

Researchers at Fox Chase Cancer Center have demonstrated that it might be possible to treat genetic diseases, including some forms of cancer, by "rescuing" the misshapen, useless proteins produced by some mutant genes.In the current issue of the Journal of Biological Chemistry, available online now, researchers detail how they were able to restore the function of a mutant human gene in a yeast model of disease by manipulating the available amounts of a so-called chaperone protein, named...

2009-01-07 18:37:32

The potential of the appetite suppressing hormone -- leptin -- may be realized after all, U.S. researchers say. The discovery of leptin, an appetite-suppressing hormone secreted by fat tissue, created great hopes for an effective treatment for obesity, but it was found the obese are unresponsive to leptin due to leptin resistance in the brain. The study, published in Cell Metabolism, found two chaperones -- 4-PBA or TUDCA -- increase leptin sensitivity as much as 10-fold and resulted in...

2008-10-03 12:00:27

Exelixis, a development-stage biotechnology company, has submitted an investigational new drug application to the FDA for XL888, a novel anticancer compound. XL888 is an orally available small molecule inhibitor of HSP90, which is a chaperone protein that promotes the activity and stability of a range of key regulatory proteins, including kinases. The activity of HSP90 is particularly prominent in tumor cells where it promotes the activity of proteins controlling growth and survival, the...

2008-10-02 18:00:30

Exelixis, Inc. (Nasdaq:EXEL) announced today that it has submitted an investigational new drug (IND) application to the U.S. Food and Drug Administration for XL888, a novel anticancer compound. XL888 is an orally available small molecule inhibitor of HSP90, which is a chaperone protein that promotes the activity and stability of a range of key regulatory proteins, including kinases. The activity of HSP90 is particularly prominent in tumor cells where it promotes the activity of proteins...

2008-09-22 09:00:12

CytRx Corporation (Nasdaq:CYTR), a biopharmaceutical research and development company engaged in the development of high-value human therapeutics, today announced the completion of its acquisition of Innovive Pharmaceuticals, Inc. CytRx purchased Innovive for total consideration of approximately 2.6 million shares of CytRx common stock, approximately $18.3 million of future performance-based milestone earn-outs, and the assumption of Innovive's liabilities. The acquired Innovive portfolio...


Word of the Day
ambsace
  • Bad luck; misfortune.
  • The smallest amount possible or the most worthless thing.
The word 'ambsace' comes from a Latin word meaning 'both'.