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Insulin Resistance Mediated By White Blood Cells
2012-08-06 09:00:59

Neutrophils' role is a surprise -- and a potential new target for treating diabetes Researchers at the University of California, San Diego School of Medicine say neutrophils, an abundant type of white blood cell typically tasked with attacking bacteria and other foreign invaders, also plays an unexpected role in mediating insulin resistance — the central characteristic of type 2 diabetes, which afflicts an estimated 26 million Americans. The findings are published in the August 5,...

2011-11-14 23:19:10

Male and female mice engineered to express the inflammatory enzyme IKKbeta in their fat tissue ate more but gained less weight. They burned sugar and fat more effectively than mice who were left unaltered. The research may shed light on how obesity and inflammation affect insulin resistance and sensitivity. In a new study, scientists report that they substantially curbed weight gain, improved metabolism, and improved the efficacy of insulin in mice by engineering them to express a specific...

2010-09-06 08:59:33

(Ivanhoe Newswire) "“ Fish oil was deemed the "miracle food of the 21st century" because of its anti-inflammatory and anti-diabetes benefits, among many others.  But until now, scientists were unsure of how this miracle vitamin actually worked. They've finally pinpointed how omega-3 fatty acids stop inflammation and reverse diabetes in obese mice. Omega-3s alleviate inflammation, especially the joint pain in arthritis, by acting on a receptor (GPR120) found in fat tissue and on...

2010-08-16 15:40:05

Inflammation-causing cells in fat tissue may explain the link between obesity and diabetes, a team of Walter and Eliza Hall Institute researchers in Melbourne, Australia, has shown. The discovery, by Professor Len Harrison and Dr John Wentworth from the institute's Autoimmunity and Transplantation division, opens the way for new anti-inflammatory treatments that prevent insulin resistance (where the body is unable to respond to and use the insulin it produces) and other complications...

2010-05-10 08:59:12

Recent decades have seen a huge increase in type 2 diabetes and cardiovascular disease. This is a result of people being less active and eating fattier diets, which can lead to obesity and, in turn, diabetes. In a thesis from the Sahlgrenska Academy at the University of Gothenburg, Sweden, researchers have discovered properties of insulin which reduce inflammation caused by obesity and can therefore lower the risk of type 2 diabetes. When you put on weight, your fat tissue grows and begins to...

2010-03-15 15:27:31

COLUMBUS, Ohio "“ An experimental oral drug has lowered blood sugar levels and inflammation in mice with Type 2 diabetes, suggesting that the medication could someday be added to the arsenal of drugs used by millions of Americans with this disease, according to new research. The drug consists of a synthetic molecule that stops the biological activity of a protein called macrophage migration inhibitory factor, or MIF. This protein is implicated in a number of diseases because it is...

2010-02-03 22:23:24

Although obesity is a risk factor for diabetes and coronary heart disease worldwide, only some obese individuals go on to develop these metabolic complications, while others are relatively protected. Defining these protective factors could help scientists prevent disease in the wider population. To this end, a research team at the Gladstone Institute of Cardiovascular Disease, led by Suneil Koliwad, MD, PhD, recently added new details that link obesity to diabetes and heart disease. When...

2009-09-07 08:26:35

Chronic inflammation within fat tissue is now recognized as a contributor to the many negative consequences that come with obesity -- from diabetes to cardiovascular disease, according to Yuichi Oike of Kumamoto University in Japan. Researchers hope a new discovery will point to a targeted therapy designed to limit the impact of the obesity epidemic. The new culprit Oike's team identified is a fat-derived protein called angiopoietin-like protein 2 (Angptl2). In mice, Angptl2 levels are...

2009-08-26 10:06:56

An exploration of the molecular links between insulin resistance and inflammation may have revealed a novel target for diabetes treatment, say scientists at the John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh of UPMC. Their findings were published earlier this month in the online version of Diabetes, one of the journals of the American Diabetes Association.Signs of low-grade systemic inflammation are not uncommon among people who have the pre-diabetic condition known as...

2009-05-29 08:01:14

Researchers at the University of California, San Francisco, and collaborators at Harvard Medical School have linked a specialized protein in human muscles to the process that clears glucose out of the bloodstream, shedding light on what goes wrong in type 2 diabetes on a cellular level.Establishing the function of this protein, which significantly is not present in mice, has broad implications for both the future study and possible therapies for diabetes, according to an article published in...


Word of the Day
drawcansir
  • A blustering, bullying fellow; a pot-valiant braggart; a bully.
This word is named for Draw-Can-Sir, a character in George Villiers' 17th century play The Rehearsal.
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