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Latest chemical biology Stories

2014-05-20 12:20:42

Scripps Research Institute Chemists at The Scripps Research Institute (TSRI) have determined the correct structure of a highly promising anticancer compound approved by the U.S. Food and Drug Administration (FDA) for clinical trials in cancer patients. The new report, published this week by the international chemistry journal Angewandte Chemie, focuses on a compound called TIC10. In the new study, the TSRI scientists show that TIC10's structure differs subtly from a version published...

2014-04-29 23:12:36

Informative webinar will provide insight on approaches to phenotypic screening for hit ID in the context of complex and novel biological systems. The live broadcast takes place on Wednesday, May 21, 2014 at 10:00am EDT (15:00 UK BST/ GMT +1). Toronto, Canada (PRWEB) April 29, 2014 Using phenotypic screens as a strategy to identify potential drug candidates has gained renewed attention in recent years. The aim is to identify chemical matter that corrects disease-relevant cellular...

2014-04-21 13:49:52

Compounds identified that stabilize retromer protein complex, which protects neurons from amyloid-beta A team of researchers from Columbia University Medical Center (CUMC), Weill Cornell Medical College, and Brandeis University has devised a wholly new approach to the treatment of Alzheimer's disease involving the so-called retromer protein complex. Retromer plays a vital role in neurons, steering amyloid precursor protein (APP) away from a region of the cell where APP is cleaved, creating...

2014-04-07 11:03:54

Chemists in The College of Arts and Sciences have, for the first time, created enzyme-like activity using peptides that are only seven amino acids long. Their breakthrough, which is the subject of a recent article in Nature Chemistry magazine (Macmillan Publishers, 2014), may revolutionize the study of modern-day enzymes, whose chains of amino acids usually number in the hundreds, and of neurological diseases, such as Alzheimer’s, which are usually characterized by small clumps of...

2014-03-05 08:29:31

Joint Publication Identifies Clinical Kinase Inhibitors that Potently Cross React with Bromodomain Epigenetic Reader Proteins OXFORD, United Kingdom and FREMONT, Calif., March 5, 2014 /PRNewswire/ -- The Structural Genomics Consortium (SGC) and DiscoveRx Corporation today announced the publication of findings that suggest compelling new multi-targeting approaches for cancer therapy. In a study entitled "Dual kinase-bromodomain inhibitors for rationally designed polypharmacology,"...

Drug Design From Genome Sequences
2014-02-10 06:22:11

Scripps Research Institute As proof-of-principle, the team designs potent anti-cancer compound In research that could ultimately lead to many new medicines, scientists from the Florida campus of The Scripps Research Institute (TSRI) have developed a potentially general approach to design drugs from genome sequence. As a proof of principle, they identified a highly potent compound that causes cancer cells to attack themselves and die. "This is the first time therapeutic small...

2014-01-24 11:40:44

Using a novel high-throughput screening process, scientists have for the first time identified molecules with the potential to block the accumulation of a toxic eye protein that can lead to early onset of glaucoma. Glaucoma is a group of diseases that can damage the eye’s optic nerve and cause vision loss and blindness. Elevated eye pressure is the main risk factor for optic nerve damage. Researchers have implicated a mutant form of a protein called myocilin as a possible root cause...

2013-12-22 23:01:04

Scientists at The Scripps Research Institute (TSRI) have demonstrated a drug-discovery strategy with a double payoff—it enables the rapid selection of chemical compounds that have a desired effect on cells and also highlights how the compounds work. La Jolla, CA (PRWEB) December 22, 2013 Scripps Research Institute Scientists Use Method to Identify Compound with Promise for Obesity-Linked Diabetes LA JOLLA, CA—December 22, 2013—Scientists at The Scripps Research Institute (TSRI) have...

2013-10-05 23:01:16

The International Chemical Biology Society (ICBS) will feature chemical biology research experts from more than 20 countries to its 2nd Annual Conference in Kyoto, Japan. Deerfield, Illinois / Kyoto, Japan (PRWEB) October 05, 2013 The International Chemical Biology Society (ICBS) will welcome chemical biology research experts from more than 20 countries to its 2nd Annual Conference in Kyoto, Japan. The ICBS conference will attract cross-disciplinary scientists from academia, nonprofit...

2013-09-30 12:48:15

Findings point to new approach to drug design Highlighting an important but unexplored area of evolution, scientists at The Scripps Research Institute (TSRI) have found evidence that, over hundreds of millions of years, an essential protein has evolved chiefly by changing how it moves, rather than by changing its basic molecular structure. The work has implications not only for the understanding of protein evolution, but also for the design of antibiotics and other drugs that target the...


Latest chemical biology Reference Libraries

Lab on a Chip
2012-04-29 22:56:20

Lab on a Chip is a peer-reviewed scientific journal published bi-weekly (24 issues per year) by the Royal Society of Chemistry (RSC). It was established in 2001 and hosts RSC’s other publications: Highlights in Chemical Technology and Highlights in Chemical Biology. The editor-in-chief is Harp Minhas. Lab on a Chip publishes original primary research and review articles on any aspect of miniaturization at the micro and nano scale. It covers a variety of disciplines including chemistry,...

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Word of the Day
attercop
  • A spider.
  • Figuratively, a peevish, testy, ill-natured person.
'Attercop' comes from the Old English 'atorcoppe,' where 'atter' means 'poison, venom' and‎ 'cop' means 'spider.' 'Coppa' is a derivative of 'cop,' top, summit, round head, or 'copp,' cup, vessel, which refers to 'the supposed venomous properties of spiders,' says the OED. 'Copp' is still found in the word 'cobweb.'
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