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Latest Chemokine Stories

2011-12-15 13:08:17

The white blood cells that fight disease and help our bodies heal are directed to sites of infection or injury by 'exit signs' — chemical signals that tell them where to pass through the blood vessel walls and into the underlying tissue. New research at the Weizmann Institute, which appeared in Nature Immunology online, shows how the cells lining blood vessel walls may act as 'selectors' by hiding the signals where only certain 'educated' white blood cells will find them. In previous...

2011-12-01 01:12:17

The ambivalent role of the CXCL12/ CXCR4 axis in heart repair The chemokine CXCL12 acts as a chemical signal which mobilizes hematopoietic and other types of stem cells to leave the bone marrow and enter the circulation. Secretion of CXCL12 also guides these cells to sites at which the perfusion of tissue is sub-optimal due to localized obstruction of blood flow. These capabilities have made CXCL12 and its cognate receptor CXCR4 interesting candidates for therapies aimed at mitigating the...

2011-10-10 19:38:23

Researchers at the Medical College of Wisconsin have shown that a protein can inhibit metastasis of colon and melanoma cancers. The findings are published in the October 10, 2011 issue of Proceedings of the National Academy of Sciences. Michael B. Dwinell, Ph.D., director of the Bobbie Nick Voss Laboratory and associate professor of microbiology and molecular genetics, is the lead author on the paper. Chemokines and chemokine receptors are extensively involved in metastasis of 23...

2011-08-20 07:00:00

Bioforce identifies several modes of action proving the modulating effect on the immune system of its flagship fresh Echinacea extract Echinaforce® Ghent, NY (PRWEB) August 20, 2011 The efficacy of Echinacea purpurea in supporting a healthy immune system is based on modulatory effects on immune function. There are many factors linked to short or long term weakening of the immune system, that reduce the body's natural defenses. Stress, lack of sleep, poor diet all can compromise the...

2011-06-27 13:21:00

MOUNTAIN VIEW, Calif., June 27, 2011 /PRNewswire/ -- ChemoCentryx, Inc. today announced that the Company's novel CCR2 antagonist significantly improves kidney function and hyperglycemia in experimental models. These data implicate CCR2-driven processes in the pathology of type 2 diabetes and associated complications such as diabetic nephropathy. Results were highlighted in a poster presentation entitled "CCR2 Antagonism Improves Renal Function and Hyperglycemia in Preclinical Models of...

2011-06-06 19:34:22

Cancer cells do not grow equally well everywhere in the body. Often, they first create the conditions in which they can grow. Many years ago researchers discovered that solid tumors attract blood vessels to ensure their supply of nutrients by secreting specific factors. Now the immunologist Dr. Uta Höpken (Tumor and Immunogenetics Research Group at the Max Delbrck Center for Molecular Medicine, MDC, Berlin-Buch in the Helmholtz Association) and the hematologist Dr. Armin Rehm...


Word of the Day
cacodemon
  • An evil spirit; a devil.
  • A nightmare.
  • In astrology, the twelfth house of a scheme or figure of the heavens: so called from its signifying dreadful things, such as secret enemies, great losses, imprisonment, etc.
'Cacodemon' comes from a Greek term meaning 'evil genius.'
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