Latest CHOL Stories

By Churchward, Matthew A Rogasevskaia, Tatiana; Brandman, David M; Khosravani, Houman; Nava, Phillip; Atkinson, Jeffrey K; Coorssen, Jens R ABSTRACT The Ca^sup 2+^-triggered merger of two apposed membranes is the defining step of regulated exocytosis. CHOL is required at critical levels in secretory vesicle membranes to enable efficient, native membrane fusion: CHOL-sphingomyelin enriched microdomains organize the site and regulate fusion efficiency, and CHOL directly supports the capacity...