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Latest Chromatin Stories

Peng Mao DNA repair
2014-08-21 02:30:00

Becky Phillips, Washington State University Scientists at Washington State University have identified a crucial step in DNA repair that could lead to targeted gene therapy for hereditary diseases such as “children of the moon” and a common form of colon cancer. Such disorders are caused by faulty DNA repair systems that increase the risk for cancer and other conditions. The findings are published in this week’s Proceedings of the National Academy of Sciences. The study was funded...

2014-06-09 14:30:56

University of North Carolina Health Care The discovery, from the lab of Brian Strahl, Ph.D., offers insights for the creation of better, more targeted therapies for various forms of cancer Twelve years ago, UNC School of Medicine researcher Brian Strahl, PhD, found that a protein called Set2 plays a role in how yeast genes are expressed – specifically how DNA gets transcribed into messenger RNA. Now his lab has found that Set2 is also a major player in DNA repair, a complicated and...

Male Fertility Relies On A Key Protein That Also Protects Against Disease
2014-05-13 10:58:14

Brett Smith for redOrbit.com - Your Universe Online Male infertility prevents many couples from being able to conceive a child and a new study published in the journal Nature Communications has found a specific protein that is a major determining factor in determining a sperm’s ability to fertilize an egg. The protein, known as Chd5, is responsible for effectively packaging DNA inside the head of a sperm, where space it at a premium. Each cell in the body contains an entire copy of...

Delivery Of Genomic Building Blocks Controlled By Enzyme
2014-03-07 10:14:25

University of Copenhagen Our DNA and its architecture are duplicated every time our cells divide. Histone proteins are key building blocks of this architecture and contain crucial information that regulates our genes. Danish researchers show how an enzyme controls reliable and high-speed delivery of histones to DNA copying hubs in our cells. This shuttling mechanism is crucial to maintain normal function of our genes and prevent disease. The results are published in the journal Nature...

2014-02-25 13:58:56

Technological discovery Cells in our body are constantly dividing to maintain our body functions. At each division, our DNA code and a whole machinery of supporting components has to be faithfully duplicated to maintain the cell’s memory of its own identity. Researchers at BRIC, University of Copenhagen, have developed a new technology that has revealed the dynamic events of this duplication process and the secrets of cellular memory. The results are published in Nature Cell Biology....

2014-02-07 23:04:16

Xtalks presents a new and informative webinar that focuses on epigenetics research to understand DNA methylation changes that occur within lineage-specific and cancer-specific chromatin states. The live webinar takes place on Wednesday, February 26, 2014 at 2pm EST (7pm GMT). Toronto, Canada (PRWEB) February 07, 2014 Transcriptional regulation is accomplished by both focal cis-regulatory elements (promoters, enhancers, and insulators) and the higher order organization of chromosomes...

2014-01-16 14:30:04

Application of global sequencing technology reveals how an activator of gene expression stays focused At a glance, DNA is a rather simple sequence of A, G, C, T bases, but once it is packaged by histone proteins into an amalgam called chromatin, a more complex picture emerges. Histones, which come in four subtypes—H2A, H2B, H3, and H4—can either coil DNA into inaccessible silent regions or untwist it to allow gene expression. To further complicate things, small chemical flags, such as...

Physical Reason For Shape Of Metaphase Chromosome Discovered
2014-01-15 07:37:00

Universitat Autonoma de Barcelona This work gives a solution to a fundamental question in structural biology: Why do metaphase chromosomes have their characteristic elongated cylindrical shape? The proposed solution is consistent with the structure of metaphase chromatin and with the nanomechanical properties of chromatin and chromosomes. It is a research at the interface between biology (higher order chromatin structure) and physical sciences (supramolecular structures and nanomaterials)....

2013-10-01 10:12:53

By detailing a process required for repairing DNA breakage, scientists at the Duke Cancer Institute have gained a better understanding of how cells deal with the barrage of damage that can contribute to cancer and other diseases. The insights, reported online the week of Sept. 30, 2013, in the journal Proceedings of the National Academy of Sciences, build on earlier work by the research team and identify new prospects for developing cancer therapies. The researchers have focused on a...

2013-04-02 10:30:31

Most cancer treatments are blunt. In an attempt to eradicate tumors, oncologists often turn to radiation or chemotherapy, which can damage healthy tissue along with the cancerous growths. New research from C. David Allis' laboratory at Rockefeller University may bring scientists closer to designing cancer therapeutics that can target tumors with pinpoint accuracy. Their findings, published last week in Science Express, follow a recent series of discoveries by several international genome...


Word of the Day
monteith
  • A large punch-bowl of the eighteenth century, usually of silver and with a movable rim, and decorated with flutings and a scalloped edge. It was also used for cooling and carrying wine-glasses.
  • A kind of cotton handkerchief having white spots on a colored ground, the spots being produced by a chemical which discharges the color.
This word is possibly named after Monteith (Monteigh), 'an eccentric 17th-century Scotsman who wore a cloak scalloped at the hem.'
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