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Latest Chronic granulomatous disease Stories

2012-06-21 22:57:55

Drugs target Nox2 enzyme directly instead of acting as antioxidants Scientists at Emory University School of Medicine have identified a new type of anti-inflammatory compound that may be useful in treating a wide range of conditions, including neurodegenerative and autoimmune diseases. These compounds inhibit the enzyme Nox2, part of a family of enzymes responsible for producing reactive oxygen species (ROS). "Nox2 inhibitors could be valuable with many conditions where inflammation...

2012-05-22 02:05:56

University of Cincinnati (UC) researchers have found that an imbalance in the regulation of certain T cells–the cells in the body that fight off infection or attack the system in certain autoimmune diseases–may put certain people at a higher risk of having recurrent cases of Clostridium difficile, or C. Diff, infection. These findings are being presented via poster during Digestive Disease Week, Monday, May 21, 2012, in San Diego. C. difficile is a bacterium that can be...

2012-02-22 21:34:08

Sometimes our immune defence attacks our own cells. When this happens in the brain we see neurodegenerative diseases such as dementia, Alzheimer´s and Parkinson´s disease. But if the the immune defence is inhibited, the results could be disastrous. Researchers at the University of Copenhagen have now discovered one of the molecular combat mechanisms in the brain that gets out of control in these diseases. In time this may enable targeted therapies to slow down the disease without...

2011-10-03 15:42:06

Researchers funded by the Biotechnology and Biological Sciences Research Council (BBSRC), among others, have identified an important cog in the molecular machinery of plant immunity - a discovery that could help crop breeders produce disease-resistant varieties to help ensure future food security. There may also be implications for treating human immune-related disorders. The research, led by Professor Gary Loake at the University of Edinburgh with colleagues from Syngenta is published this...

2010-12-30 13:20:39

NIH study could improve care for chronic granulomatous disease Investigators at the National Institutes of Health have observed that the survival rate of people with a rare immunodeficiency disease called chronic granulomatous disease (CGD) is greatly improved when even very low levels of microbe-killing molecules are present. Because production of these molecules, made by an enzyme called NADPH oxidase, can be predicted from genetic analysis, a patient's risk for severe CGD could be assessed...

2010-10-12 16:39:47

A deficiency in one of the immune system's enzymes affects the severity of autoimmune diseases such as MS, and explains why the course of these diseases can vary so much. New findings give an insight into how this enzyme deficiency can be diagnosed, and could lead to new medicines, reveals a thesis from the Sahlgrenska Academy. Multiple sclerosis (MS) and Guillain-Barr© syndrome (GBS) "“ the two autoimmune diseases covered by the thesis "“ can follow vastly different courses,...

2009-10-29 14:12:49

Two genetic mutations that may put individuals at increased risk of fungal infections have been identified by scientists from UCL and Radboud University, increasing understanding about the genetic basis of these infections and potentially aiding the development of new treatments. The two separate studies, published today in the New England Journal of Medicine, mark a significant step in the understanding of genetic susceptibility to fungal diseases. The findings have implications for people...

2009-10-09 13:10:14

New findings related to an uncommon genetic disorder may impact diagnosis and treatment of inflammatory bowel disease New findings related to an uncommon genetic disorder may impact the diagnosis and treatment of inflammatory bowel disease (IBD), the most common chronic gastrointestinal illness in children and teens. Two million Americans have IBD which involves inflammation of the gastrointestinal tract. Researchers from the United States and Canada have identified a genetic defect not...

2008-08-13 18:00:43

By Barry Nelson A PIONEERING North-East stem cell unit is carrying outmore lifesaving transplants than ever before, after the Government agreed to increase its funding. The Stem Cell Transplant Unit for Primary Immuno-deficiency, at Newcastle General Hospital, is one of only two specialist units in the country. Along with the stem cell transplant unit at Great Ormond Street Children?s Hospital, in London, the Newcastle unit provides a service to roughly half the UK. Equipped with...