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Latest Ciliopathy Stories

2014-03-04 16:15:59

Discovery advances efforts to replace damaged heart muscle In a study that began in a pair of infant siblings with a rare heart defect, Johns Hopkins researchers say they have identified a key molecular switch that regulates heart cell division and normally turns the process off around the time of birth. Their research, they report, could advance efforts to turn the process back on and regenerate heart tissue damaged by heart attacks or disease. "This study offers hope that we can...

Critical Protein For Healthy Cell Growth In Mammals Discovered
2014-01-28 12:37:01

Penn State University A team of researchers from Penn State University and the University of California has discovered a protein that is required for the growth of tiny, but critical, hair-like structures called cilia on cell surfaces. The discovery has important implications for human health because lack of cilia can lead to serious diseases such as polycystic kidney disease, blindness and neurological disorders. "If we want to better understand and treat diseases related to cilium...

2013-09-06 12:26:52

Study uses induced pluripotent stem cells to identify kidney disease defect New research has uncovered a process that is defective in patients with autosomal dominant polycystic kidney disease, a common cause of kidney failure. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), point to a new potential strategy for preventing and treating the disease. Polycystic kidney disease (PKD), the fourth leading cause of kidney failure...

Research Reveals Clues About Molecules And Cilia
2013-05-13 11:15:34

Johns Hopkins Medicine Experiments at Johns Hopkins have unearthed clues about which protein signaling molecules are allowed into hollow, hair-like "antennae," called cilia, that alert cells to critical changes in their environments. Researchers found that the size limit for entry is much greater than previously thought, allowing most of a cell's proteins into cilia. The researchers believe that the specific collection of proteins in each cilium, customized to the needs of each cell...

2012-11-05 15:04:16

Studies investigate the potential of several drugs for the treatment of patients with diabetes or kidney disease Three late-breaking studies presented during the American Society of Nephrology's Annual Kidney Week provide new information on drugs being tested in patients with diabetes or kidney disease. Hans-Henrik Parving, MD (University of Copenhagen, in Denmark) and his colleagues investigated whether the drug aliskiren might improve the prognosis of patients with type 2 diabetes who...

2012-05-09 14:36:09

Tiny organelles called primary cilia hold the key to combat inflammation Scientists from Queen Mary, University of London have found a new therapeutic target to combat inflammation. The research, published in the journal Cellular and Molecular Life Sciences, revealed tiny organelles called primary cilia are important for regulating inflammation. The findings could lead to potential therapies for millions of people who suffer from arthritis. Dr Martin Knight who led the research at...

2012-04-25 09:45:04

Primary cilia are hair-like structures which protrude from almost all mammalian cells. They are thought to be sensory and involved in sampling the cell's environment. New research, published in BioMed Central's open access journal Cilia, launched today, shows that cilia on cells in the retina and liver are able to make stable connections with each other - indicating that cilia not only are able to sense their environment but are also involved in cell communication. Primary cilia are...

2011-12-06 23:17:59

Research presented at ASCB annual meeting After a four-week course of the vasodilator hormone relaxin, kidney function and blood flow immediately improved in lab rats genetically altered to model polycystic kidney disease (PKD), a life-threatening genetic disorder, according to research presented on Dec. 6 at the American Society for Cell Biology Annual Meeting in Denver. In addition to widening the blood vessels, relaxin lowered the collagen scores of the PKD rats, indicating that the...

2011-12-06 23:15:40

Research presented at ASCB annual meeting Is obesity a ciliopathy, a disorder such as polycystic kidney disease (PKD), which is triggered by a defect in the microscopic hair-like cilia that protrude from virtually every cell of humans and other vertebrates? University of Alabama, Birmingham (UAB) researchers told the American Society for Cell Biology (ASCB) 2011 Annual Meeting in Denver on Dec. 6 that mutations in primary cilia may scramble signaling pathways in the hypothalamus, the...

2011-04-05 00:05:23

Discovery points to a potential co-contributor to cilia-related diseases Researchers at the University of Massachusetts Medical School have described a previously unknown role for the cilia protein IFT88 in mitosis, the process by which a dividing cell separates its chromosomes containing the cell's DNA into two identical sets of new daughter cells. Published in advance online by Nature Cell Biology, this newly discovered function for IFT88 suggests a possible alternative or contributory...


Word of the Day
bodacious
  • Remarkable; prodigious.
  • Audacious; gutsy.
  • Completely; extremely.
  • Audaciously; boldly.
  • Impressively great in size; enormous; extraordinary.
This word is probably from the dialectal 'boldacious,' a blend of 'bold' and 'audacious.'
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